Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo 1H MRS study.

Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo 1H MRS study. Research Abstract Details 

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Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo 1H MRS study. Abstract Text:

Frey,Jeffrey A Stanley,Fabiano G Nery,E Serap Monkul,Mark A Nicoletti,Hua-Hsuan Chen,John P Hatch,Sheila C Caetano,Oswaldo Ortiz, Kapczinski,Jair C Soares, Frey,Jeffrey A Stanley,Fabiano G Nery,E Serap Monkul,Mark A Nicoletti,Hua-Hsuan Chen,John P Hatch,Sheila C Caetano,Oswaldo Ortiz, Kapczinski,Jair C Soares,

OBJECTIVES: While the pathophysiology of bipolar disorder (BD) remains to be elucidated, postmortem and neuroimaging studies have suggested that abnormalities in the dorsolateral prefrontal cortex (DLPFC) are implicated. We compared the levels of specific brain chemicals of interest measured with proton magnetic resonance spectroscopy ((1)H MRS) in medication-free BD subjects and age- and gender-matched healthy controls. We hypothesized that BD subjects would present abnormal cellular metabolism within the DLPFC, as reflected by lower N-acetyl-aspartate (NAA) and creatine + phosphocreatine (Cr + PCr). METHODS: Thirty-two medication-free BD subjects (33.8 +/- 10.2 years) and 32 matched controls (33.8 +/- 9.0 years) underwent a short echo-time (TE = 30 ms) (1)H MRS. An 8-cm(3) single voxel was placed in the left DLPFC, and individual concentrations of NAA, Cr + PCr, choline-containing compounds (GPC + PC), myo-inositol, and glutamate were obtained, using the water signal as an internal reference. RESULTS: BD subjects had lower Cr + PCr [F((1,62)) = 5.85; p = 0.018; one-way analysis of variance (ANOVA)] and lower GPC + PC [F((1,62)) = 5.79; p = 0.019; one-way ANOVA] levels in the left DLPFC. No significant differences were observed for other brain metabolites. CONCLUSIONS: These findings provide further evidence that the pathophysiology of BD involves impairment in the DLPFC. Our findings can be interpreted as evidence for reduced cellular energy and phospholipid metabolism, consistent with the hypothesis of mitochondrial dysfunction in BD.

Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo 1H MRS study. Publishing Authors By Initials

BN Frey,JA Stanley,FG Nery,ES Monkul,MA Nicoletti,HH Chen,JP Hatch,SC Caetano,O Ortiz,F Kapczinski,JC Soares,BN Frey,JA Stanley,FG Nery,ES Monkul,MA Nicoletti,HH Chen,JP Hatch,SC Caetano,O Ortiz,F Kapczinski,JC Soares,

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Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo 1H MRS study. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Bipolar disorders

VOLUME: 9 Suppl 1

Page Numbers: 119-27

Journal Abbreviation: Bipolar Disord

ISSN: 1398-5647

DAY: 4

MONTH: Jun

YEAR: 2007

Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo 1H MRS study. Information

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LANGUAGE: eng

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AFFILIATION: MOOD-CNS Program, Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, TX 78229, USA. benicio.frey@gmail.com

Country: Denmark

AGENCY: United States NCRR

GRANT: RR020571

ACRONYM: RR

MEDLINETA: Bipolar Disord

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