[Aberrant expression of MUC2 and MUC3 genes in gastric carcinoma and its significance]

[Aberrant expression of MUC2 and MUC3 genes in gastric carcinoma and its significance] Research Abstract Details 

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[Aberrant expression of MUC2 and MUC3 genes in gastric carcinoma and its significance] Abstract Text:

R Wang,D Fang,W Liu,Y Luo,

OBJECTIVES: To explore the clinicopathological significance of the expression of MUC2 (mucin 2) and MUC3 (mucin 3) genes in tissues of the normal gastric mucosa, intestinal metaplasia (IM) and gastric carcinoma. METHODS: MUC2 and MUC3 apomucins were detected by immunohistochemistry; MUC2 and MUC3 mRNAs were detected by in situ hybridization. RESULTS: In the normal stomach, antibody detecting MUC2 apomucin and oligonucleotide probe detecting MUC2 mRNA were not reactive with mucus-producing cells in the superficial epithelium and neck, which were weakly reactive with antibody and probe detecting MUC3. In the duodenum, MUC2 apomucin and mRNA were found at the peri- and supranuclear area of goblet cells, but MUC3 apomucin and mRNA were at the cytoplasm of goblet cells and columnar cells. MUC2 and MUC3 apomucins and its mRNAs were found in 85.2%, 88.9% and 31.6%; 57.1% of specimens of IM, 67.4%, 66.7% and 57.9%, 43.6% of specimens of gastric carcinoma. There were no associations between expressions of MUC2 and MUC3 genes and different types of IM. Patients with moderate/well differentiation had higher proportion of MUC2 apomucin expression than those with poor differentiation (P < 0.05), and patients with positive staining of MUC3 apomucin in the cancerous tissues had higher proportions of metastasis of lymph nodes (P < 0.01), serosal invasion (P < 0.05) and clinical stages III-IV (P < 0.05). CONCLUSIONS: MUC2 and MUC3 genes are mainly expressed in the mucosa of the duodenum, and marked expression is seen during the neoplastic transformation of stomach mucosa. MUC3 apomucin might have a poor prognostic significance.

[Aberrant expression of MUC2 and MUC3 genes in gastric carcinoma and its significance] Publishing Authors By Initials

R Wang,D Fang,W Liu,Y Luo,

For similar neoplasms: neoplasms by site: digestive system neoplasms: gastrointestinal neoplasms: stomach neoplasms research abstracts see: neoplasms: neoplasms by site: digestive system neoplasms: gastrointestinal neoplasms: stomach neoplasms research

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[Aberrant expression of MUC2 and MUC3 genes in gastric carcinoma and its significance] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Chinese medical journal

VOLUME: 113

Page Numbers: 502-7

Journal Abbreviation: Chin. Med. J.

ISSN: 0366-6999

DAY: 1

MONTH: Jun

YEAR: 2000

[Aberrant expression of MUC2 and MUC3 genes in gastric carcinoma and its significance] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 7513795

[Aberrant expression of MUC2 and MUC3 genes in gastric carcinoma and its significance] Keywords Mesh Terms:

KEYWORDS: Stomach Neoplasms

MESH TERMS: genetics

Chemical & Substance for Abstract: [Aberrant expression of MUC2 and MUC3 genes in gastric carcinoma and its significance] Information

Substance Name: Mucins

Registry Number: 0

Grant and Affiliation Information for [Aberrant expression of MUC2 and MUC3 genes in gastric carcinoma and its significance]

AFFILIATION: Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.

Country: China

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MEDLINETA: Chin Med J (Engl)

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