Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer.

Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer. Research Abstract Details 

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Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer. Abstract Text:

Richard G Stevens,Helen Swede,Christopher D Heinen,Melissa Jablonski,Michael Grupka,Barry Ross,Melissa Parente,Jennifer S Tirnauer,Charles Giardina,Thiruchandurai V Rajan,Daniel W Rosenberg,Joel Levine,

Early detection is crucial in the prevention of colorectal cancer (CRC) deaths. The earliest detectable neoplastic lesion in the colon is the aberrant crypt foci (ACF). A major question is whether ACF are precursors of CRC, and thus, early biomarkers for CRC risk. If so, we hypothesized that the number of ACF would be higher in patients who had a family history of CRC compared to patients without. We counted ACF in the distal 20cm of colon/rectum during 103 colonoscopic examinations using a prototype Close Focus Colonoscope (Olympus Corp.) with methylene blue chromendoscopy. Each patient was asked whether they had a family history of CRC in a first degree relative, or a personal history of CRC or adenoma. Patients answering 'no' to these questions (n=17) had a mean number of ACF of 4.4; the mean was significantly higher in the patients with a positive family history of CRC (9.0, p<0.01; n=43) or a personal history of advanced adenoma (7.5, p<0.05; n=34).

Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer. Publishing Authors By Initials

RG Stevens,H Swede,CD Heinen,M Jablonski,M Grupka,B Ross,M Parente,JS Tirnauer,C Giardina,TV Rajan,DW Rosenberg,J Levine,

For similar neoplasms: precancerous conditions research abstracts see: neoplasms: precancerous conditions research

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Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer letters

VOLUME: 248

Page Numbers: 262-8

Journal Abbreviation: Cancer Lett.

ISSN: 0304-3835

DAY: 6

MONTH: 09

YEAR: 2006

Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer. Information

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LANGUAGE: eng

NlmUniqueID: 7600053

Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer. Keywords Mesh Terms:

KEYWORDS: Precancerous Conditions

MESH TERMS: pathology

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Grant and Affiliation Information for Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer.

AFFILIATION: Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, CT, USA. bugs@neuron.uchc.edu

Country: Ireland

AGENCY: United States NCI

GRANT: CA81428

ACRONYM: CA

MEDLINETA: Cancer Lett

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