ABCC8 and ABCC9: ABC transporters that regulate K+ channels.

ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Research Abstract Details 

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ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Abstract Text:

Joseph Bryan,Alvaro ,Xinna Zhang,Martina ,Gisela Drews,Peter Krippeit-Drews,Lydia Aguilar-Bryan,

The sulfonylurea receptors (SURs) ABCC8/SUR1 and ABCC9/SUR2 are members of the C-branch of the transport adenosine triphosphatase superfamily. Unlike their brethren, the SURs have no identified transport function; instead, evolution has matched these molecules with K(+) selective pores, either K(IR)6.1/KCNJ8 or K(IR)6.2/KCNJ11, to assemble adenosine triphosphate (ATP)-sensitive K(+) channels found in endocrine cells, neurons, and both smooth and striated muscle. Adenine nucleotides, the major regulators of ATP-sensitive K(+) (K(ATP)) channel activity, exert a dual action. Nucleotide binding to the pore reduces the activity or channel open probability, whereas Mg-nucleotide binding and/or hydrolysis in the nucleotide-binding domains of SUR antagonize this inhibitory action to stimulate channel openings. Mutations in either subunit can alter this balance and, in the case of the SUR1/KIR6.2 channels found in neurons and insulin-secreting pancreatic beta cells, are the cause of monogenic forms of hyperinsulinemic hypoglycemia and neonatal diabetes. Additionally, the subtle dysregulation of K(ATP) channel activity by a K(IR)6.2 polymorphism has been suggested as a predisposing factor in type 2 diabetes mellitus. Studies on K(ATP) channel null mice are clarifying the roles of these metabolically sensitive channels in a variety of tissues.

ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Publishing Authors By Initials

J Bryan,A ,X Zhang,M ,G Drews,P Krippeit-Drews,L Aguilar-Bryan,

For similar proteins: receptors, drug research abstracts see: proteins: receptors, drug research

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ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Journal Published:

PUBLICATION TYPE: Review

Journal: Pflügers Archiv : European journal of physiology

VOLUME: 453

Page Numbers: 703-18

Journal Abbreviation: Pflugers Arch.

ISSN: 0031-6768

DAY: 8

MONTH: 08

YEAR: 2006

ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Information

Number of References: 158

LANGUAGE: eng

NlmUniqueID: 154720

ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Keywords Mesh Terms:

KEYWORDS: Receptors, Drug

MESH TERMS: physiology

Chemical & Substance for Abstract: ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Information

Substance Name: Glucagon-Like Peptide 1

Registry Number: 89750-14-1

Grant and Affiliation Information for ABCC8 and ABCC9: ABC transporters that regulate K+ channels.

AFFILIATION: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. jbryan@bcm.tmc.edu

Country: Germany

AGENCY: United States NIDDK

GRANT: DK52771

ACRONYM: DK

MEDLINETA: Pflugers Arch

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