ABCA1 polymorphisms and Alzheimer's disease.

ABCA1 polymorphisms and Alzheimer's disease. Research Abstract Details 

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ABCA1 polymorphisms and Alzheimer's disease. Abstract Text:

Fabienne ,Danielle Compton,Meridith Womick,Sampath Arepalli,Omanma Adighibe,Ling Li,Jordi ,John Hardy,

In our search for genetic factors related to the development of Alzheimer's disease, we have genotyped 332 pedigrees for three coding polymorphisms in the ABCA1 gene, two of which are known to alter plasma cholesterol levels, as well as a non-coding polymorphism within the promoter. We show an apparent weak association of rs2230806 (p-value=0.01) with the disease in a sibpair series of Alzheimer's disease that had shown previously evidence for linkage to the chromosome 9 locus where ABCA1 maps.

ABCA1 polymorphisms and Alzheimer's disease. Publishing Authors By Initials

F ,D Compton,M Womick,S Arepalli,O Adighibe,L Li,J ,J Hardy,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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ABCA1 polymorphisms and Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Neuroscience letters

VOLUME: 416

Page Numbers: 180-3

Journal Abbreviation: Neurosci. Lett.

ISSN: 0304-3940

DAY: 7

MONTH: 02

YEAR: 2007

ABCA1 polymorphisms and Alzheimer's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7600130

ABCA1 polymorphisms and Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: ABCA1 polymorphisms and Alzheimer's disease. Information

Substance Name: ATP-Binding Cassette Transporters

Registry Number: 0

Grant and Affiliation Information for ABCA1 polymorphisms and Alzheimer's disease.

AFFILIATION: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Room 1A1015 MSC 3707, Bethesda, MD 20892-3707, USA. wavrant@mail.nih.gov

Country: Ireland

AGENCY: United States NIA

GRANT: U24 AG21886

ACRONYM: AG

MEDLINETA: Neurosci Lett

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