Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos.

Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos. Research Abstract Details 

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Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos. Abstract Text:

Kyoung Hwa Jang,Soon-Chun Chung,Jongheon Shin,So-Hyoung Lee,Tae-Im Kim,Hyi-Seung Lee,Ki-Bong Oh,

Four aaptamines (1-4), 1H-benzo[de][1,6]-naphthyridine alkaloids, were isolated from the marine sponge Aaptos aaptos and their inhibitory activities against sortase A (SrtA), an enzyme that plays a key role in cell wall protein anchoring and virulence in Staphylococcus aureus, were evaluated. Isoaaptamine (2) was a potent inhibitor of SrtA, with an IC(50) value of 3.7+/-0.2 microg/mL. The suppression of fibronectin-binding activity by isoaaptamine (2) highlights its potential for the treatment of S. aureus infections via inhibition of SrtA activity. Our studies have identified a series of SrtA inhibitors, providing the basis for further development of potent inhibitors.

Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos. Publishing Authors By Initials

KH Jang,SC Chung,J Shin,SH Lee,TI Kim,HS Lee,KB Oh,

For similar bacteria: gram-positive bacteria: gram-positive cocci: staphylococcaceae: staphylococcus: staphylococcus aureus research abstracts see: bacteria: gram-positive bacteria: gram-positive cocci: staphylococcaceae: staphylococcus: staphylococcus aureus research

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Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 5366-9

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 11

MONTH: 08

YEAR: 2007

Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos. Keywords Mesh Terms:

KEYWORDS: Staphylococcus aureus

MESH TERMS: growth & development

Chemical & Substance for Abstract: Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos. Information

Substance Name: Cysteine Endopeptidases

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos.

AFFILIATION: Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 110-460, Republic of Korea.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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