[A986S polymorphism of calcium-sensing receptor gene is not related to bone mineral density or bone size in premenopausal Chinese women]

[A986S polymorphism of calcium-sensing receptor gene is not related to bone mineral density or bone size in premenopausal Chinese women] Research Abstract Details 

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[A986S polymorphism of calcium-sensing receptor gene is not related to bone mineral density or bone size in premenopausal Chinese women] Abstract Text:

Xiao-yang Mo,Yuan-yuan Zhang,Shu-feng Lei,Hong-wen Deng,

OBJECTIVE: To investigate the association of a calcium-sensing receptor (CaSR) gene missense polymorphism, 986Ala/Ser (A986S), with bone mineral density (BMD) and bone size in healthy Chinese premenopausal women. METHODS: A total of 285 healthy Chinese premenopausal women (20.0 to 41.9 years of age) of Han nationality in the urban area of Shanghai were recruited for this study. The BMD and bone size of the spine and hip were measured by dual-energy X-ray absorptiometry. All the subjects were genotyped at the CaSR A986S site in exon 7 with polymerase chain reaction followed by restriction enzyme BsaHI digestion. The presence of the restriction fragment site was represented by alanine (A), while its absence by serine (S), rendering the genotypes AA, AS, and SS. RESULTS: The genotype AS was rare and SS absent in these Chinese women, and no significant differences in the BMD or bone size of either the spine or hip were found between the two genotypes. CONCLUSION: Given the important role of the CaSR in calcium metabolism, further studies with useful genetic markers may have better chances to define the association of the CaSR gene with bone phenotype variations.

[A986S polymorphism of calcium-sensing receptor gene is not related to bone mineral density or bone size in premenopausal Chinese women] Publishing Authors By Initials

XY Mo,YY Zhang,SF Lei,HW Deng,

For similar musculoskeletal system: skeleton: bone and bones: spine research abstracts see: musculoskeletal system: skeleton: bone and bones: spine research

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[A986S polymorphism of calcium-sensing receptor gene is not related to bone mineral density or bone size in premenopausal Chinese women] Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Di 1 jun yi da xue xue bao = Academic journal of t

VOLUME: 24

Page Numbers: 1097-101, 1122

Journal Abbreviation: Di Yi Jun Yi Da Xue Xue Bao

ISSN: 1000-2588

DAY: 3

MONTH: Oct

YEAR: 2004

[A986S polymorphism of calcium-sensing receptor gene is not related to bone mineral density or bone size in premenopausal Chinese women] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 9426110

[A986S polymorphism of calcium-sensing receptor gene is not related to bone mineral density or bone size in premenopausal Chinese women] Keywords Mesh Terms:

KEYWORDS: Spine

MESH TERMS: anatomy & histology

Chemical & Substance for Abstract: [A986S polymorphism of calcium-sensing receptor gene is not related to bone mineral density or bone size in premenopausal Chinese women] Information

Substance Name: Receptors, Calcium-Sensing

Registry Number: 0

Grant and Affiliation Information for [A986S polymorphism of calcium-sensing receptor gene is not related to bone mineral density or bone size in premenopausal Chinese women]

AFFILIATION: Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha 410081, China. moxiaoyang@yahoo.com.cn

Country: China

AGENCY: United States NIGMS

GRANT: R01 GM 60402-01

ACRONYM: GM

MEDLINETA: Di Yi Jun Yi Da Xue Xue Bao

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