A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs.

A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. Research Abstract Details 

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A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. Abstract Text:

V A Feodorova,L N Pan'kina,E P Savostina,L V Sayapina,V L Motin,S V Dentovskaya,R Z Shaikhutdinova,S A Ivanov,B Lindner,A N Kondakova,O V Bystrova,N A Kocharova,S N Senchenkova,O Holst,G B Pier,Y A Knirel,A P Anisimov,V A Feodorova,L N Pan'kina,E P Savostina,L V Sayapina,V L Motin,S V Dentovskaya,R Z Shaikhutdinova,S A Ivanov,B Lindner,A N Kondakova,O V Bystrova,N A Kocharova,S N Senchenkova,O Holst,G B Pier,Y A Knirel,A P Anisimov,

The lpxM mutant of the live vaccine Yersinia pestis EV NIIEG strain synthesising a less toxic penta-acylated lipopolysaccharide was found to be avirulent in mice and guinea pigs, notably showing no measurable virulence in Balb/c mice which do retain some susceptibility to the parental strain itself. Twenty-one days after a single injection of the lpxM-mutant, 85-100% protection was achieved in outbred mice and guinea pigs, whereas a 43% protection rate was achieved in Balb/c mice given single low doses (10(3) to 2.5 x 10(4) CFU) of this vaccine. A subcutaneous challenge with 2000 median lethal doses (equal to 20,000 CFU) of fully virulent Y. pestis 231 strain, is a 6-10-fold higher dose than that which the EV NIIEG itself can protect against.

A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. Publishing Authors By Initials

VA Feodorova,LN Pan'kina,EP Savostina,LV Sayapina,VL Motin,SV Dentovskaya,RZ Shaikhutdinova,SA Ivanov,B Lindner,AN Kondakova,OV Bystrova,NA Kocharova,SN Senchenkova,O Holst,GB Pier,YA Knirel,AP Anisimov,VA Feodorova,LN Pan'kina,EP Savostina,LV Sayapina,VL Motin,SV Dentovskaya,RZ Shaikhutdinova,SA Ivanov,B Lindner,AN Kondakova,OV Bystrova,NA Kocharova,SN Senchenkova,O Holst,GB Pier,YA Knirel,AP Anisimov,

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A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Vaccine

VOLUME: 25

Page Numbers: 7620-8

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 14

MONTH: 09

YEAR: 2007

A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. Information

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LANGUAGE: eng

NlmUniqueID: 8406899

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Grant and Affiliation Information for A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs.

AFFILIATION: Russian State Anti-Plague Research Institute Microbe, 46 Universitetskaya Street, Saratov 410005, Russia. feodorova@san.ru

Country: Netherlands

AGENCY: United States NIAID

GRANT: AI-46706-06

ACRONYM: AI

MEDLINETA: Vaccine

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