A YAC-based contig of 1.5 Mb spanning the human multidrug resistance gene region and delineating the amplification unit in three human multidrug-resistant cell lines.

A YAC-based contig of 1.5 Mb spanning the human multidrug resistance gene region and delineating the amplification unit in three human multidrug-resistant cell lines. Research Abstract Details 

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A YAC-based contig of 1.5 Mb spanning the human multidrug resistance gene region and delineating the amplification unit in three human multidrug-resistant cell lines. Abstract Text:

K Torigoe,S Sato,H Kusaba,K Kohno,M Kuwano,K Okumura,E D Green,L C Tsui,S W Scherer,D Schlessinger,M Wada,

A contig of 21 nonchimeric yeast artificial chromosomes (YACs) has been assembled across 1.5 Mb of the multidrug resistance (MDR) gene region located at 7q21, and formatted with four previously reported probes, six newly isolated probes, and three sequence-tagged sites (STSs) from internal and end fragments of YACs. A physical map of rare cutter restriction enzyme sites across the region was also constructed by pulsed-field gel electrophoretic (PFGE) analysis of four overlapping YAC clones. The amplification unit of this region in different cell lines was then determined by Southern blot analysis on the basis of the physical map and probes. Amplified DNA was located in extrachromosomal elements in human MDR cell lines studied here, and the size of the amplification unit was determined to be discrete in one MDR amplification but variable in others.

A YAC-based contig of 1.5 Mb spanning the human multidrug resistance gene region and delineating the amplification unit in three human multidrug-resistant cell lines. Publishing Authors By Initials

K Torigoe,S Sato,H Kusaba,K Kohno,M Kuwano,K Okumura,ED Green,LC Tsui,SW Scherer,D Schlessinger,M Wada,

For similar genetic structures: genome: genome components: sequence tagged sites research abstracts see: genetic structures: genome: genome components: sequence tagged sites research

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A YAC-based contig of 1.5 Mb spanning the human multidrug resistance gene region and delineating the amplification unit in three human multidrug-resistant cell lines. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Genome research

VOLUME: 5

Page Numbers: 233-44

Journal Abbreviation:

ISSN: 1088-9051

DAY: 3

MONTH: Oct

YEAR: 1995

A YAC-based contig of 1.5 Mb spanning the human multidrug resistance gene region and delineating the amplification unit in three human multidrug-resistant cell lines. Information

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LANGUAGE: eng

NlmUniqueID: 9518021

A YAC-based contig of 1.5 Mb spanning the human multidrug resistance gene region and delineating the amplification unit in three human multidrug-resistant cell lines. Keywords Mesh Terms:

KEYWORDS: Sequence Tagged Sites

MESH TERMS: genetics

Chemical & Substance for Abstract: A YAC-based contig of 1.5 Mb spanning the human multidrug resistance gene region and delineating the amplification unit in three human multidrug-resistant cell lines. Information

Substance Name: multidrug resistance protein 3

Registry Number: 0

Grant and Affiliation Information for A YAC-based contig of 1.5 Mb spanning the human multidrug resistance gene region and delineating the amplification unit in three human multidrug-resistant cell lines.

AFFILIATION: Department of Biochemistry, Kyushu University School of Medicine, Fukuoka, Japan.

Country: UNITED STATES

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MEDLINETA: Genome Res

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