A unique mucin immunoenhancing peptide with antitumor properties.

A unique mucin immunoenhancing peptide with antitumor properties. Research Abstract Details 

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A unique mucin immunoenhancing peptide with antitumor properties. Abstract Text:

Lynn M Herbert,Joseph F Grosso,Mantley Dorsey,Tihui Fu,Iafa Keydar,Mabel A Cejas,Daniel H Wreschner,Nechama Smorodinski,Diana M Lopez,

Implantation of DA-3 mammary tumor cells into BALB/c mice results in tumor growth, metastatic lesions, and death. These cells were transfected with genes encoding for either the transmembrane (DA-3/TM) or secreted (DA-3/sec) form of human mucin 1 (MUC1). Although the gene for the secreted form lacks the transmembrane and cytoplasmic domains, the 5' sequences of these mucins are identical; however, the gene for the secreted mucin isoform ends with a sequence encoding for a unique 11 amino acid peptide. The DA-3/TM or DA-3 cells transfected with the neomycin vector only (DA-3/neo) have the same in vivo growth characteristics as the parent cell line. In contrast, DA-3/sec cells fail to grow when implanted in immunocompetent BALB/c animals. DA-3/sec cells implanted in nude mice resulted in tumor development verifying the tumorigenic potential of these cells. Pre-exposure of BALB/c mice to DA-3/sec cells afforded protection against challenge with DA-3/TM or DA-3/neo mammary tumors and the unrelated tumors K7, an osteosarcoma, and RENCA, a renal cell carcinoma. Partial protection against subsequent tumor challenges was also achieved by substituting the 11 amino acid peptide found only in the secreted MUC1 isoform, for the live DA-3/sec cells. Notably, the efficacy of this peptide is not strain restricted because it also retarded the growth of Lewis lung carcinoma cells in C57 BL/6 mice. These findings reveal that a unique peptide present in the secreted MUC1 has immunoenhancing properties and may be a potential agent for use in immunotherapy.

A unique mucin immunoenhancing peptide with antitumor properties. Publishing Authors By Initials

LM Herbert,JF Grosso,M Dorsey,T Fu,I Keydar,MA Cejas,DH Wreschner,N Smorodinski,DM Lopez,

For similar peptides: peptide fragments research abstracts see: peptides: peptide fragments research

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A unique mucin immunoenhancing peptide with antitumor properties. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer research

VOLUME: 64

Page Numbers: 8077-84

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 1

MONTH: Nov

YEAR: 2004

A unique mucin immunoenhancing peptide with antitumor properties. Information

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LANGUAGE: eng

NlmUniqueID: 2984705

A unique mucin immunoenhancing peptide with antitumor properties. Keywords Mesh Terms:

KEYWORDS: Peptide Fragments

MESH TERMS: physiology

Chemical & Substance for Abstract: A unique mucin immunoenhancing peptide with antitumor properties. Information

Substance Name: Peptide Fragments

Registry Number: 0

Grant and Affiliation Information for A unique mucin immunoenhancing peptide with antitumor properties.

AFFILIATION: Department of Microbiology & Immunology, University of Miami School of Medicine, Miami, Florida 33101, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA25583

ACRONYM: CA

MEDLINETA: Cancer Res

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