A unified model explaining the offsets of overlapping and near-overlapping prokaryotic genes.

A unified model explaining the offsets of overlapping and near-overlapping prokaryotic genes. Research Abstract Details 

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A unified model explaining the offsets of overlapping and near-overlapping prokaryotic genes. Abstract Text:

Carl Kingsford,Arthur L Delcher,Steven L Salzberg,

Overlapping genes are a common phenomenon. Among sequenced prokaryotes, more than 29% of all annotated genes overlap at least 1 of their 2 flanking genes. We present a unified model for the creation and repair of overlaps among adjacent genes where the 3' ends either overlap or nearly overlap. Our model, derived from a comprehensive analysis of complete prokaryotic genomes in GenBank, explains the nonuniform distribution of the lengths of such overlap regions far more simply than previously proposed models. Specifically, we explain the distribution of overlap lengths based on random extensions of genes to the next occurring downstream stop codon. Our model also provides an explanation for a newly observed (here) pattern in the distribution of the separation distances of closely spaced nonoverlapping genes. We provide evidence that the newly described biased distribution of separation distances is driven by the same phenomenon that creates the uneven distribution of overlap lengths. This suggests a dynamic picture of continual overlap creation and elimination.

A unified model explaining the offsets of overlapping and near-overlapping prokaryotic genes. Publishing Authors By Initials

C Kingsford,AL Delcher,SL Salzberg,

For similar cells: prokaryotic cells research abstracts see: cells: prokaryotic cells research

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A unified model explaining the offsets of overlapping and near-overlapping prokaryotic genes. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular biology and evolution

VOLUME: 24

Page Numbers: 2091-8

Journal Abbreviation: Mol. Biol. Evol.

ISSN: 0737-4038

DAY: 21

MONTH: 07

YEAR: 2007

A unified model explaining the offsets of overlapping and near-overlapping prokaryotic genes. Information

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LANGUAGE: eng

NlmUniqueID: 8501455

A unified model explaining the offsets of overlapping and near-overlapping prokaryotic genes. Keywords Mesh Terms:

KEYWORDS: Prokaryotic Cells

MESH TERMS: metabolism

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Grant and Affiliation Information for A unified model explaining the offsets of overlapping and near-overlapping prokaryotic genes.

AFFILIATION: Center for Bioinformatics and Computational Biology, Institute for Advanced Computer Studies, University of Maryland, USA. carlk@umiacs.umd.edu

Country: United States

AGENCY: United States NLM

GRANT: R01-LM06845

ACRONYM: LM

MEDLINETA: Mol Biol Evol

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