A ubiquitin stress response induces altered proteasome composition.

A ubiquitin stress response induces altered proteasome composition. Research Abstract Details 

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A ubiquitin stress response induces altered proteasome composition. Abstract Text:

Ubiquitin-dependent protein degradation is essential for cells to survive many environmental stresses. Thus, it may be necessary to buffer ubiquitin and proteasome pools against fluctuation. Proteasome levels are tightly regulated, and proteasome deficiency stimulates a stress response. Here we report a novel pathway of cellular response to ubiquitin depletion. Unlike proteasome stress, ubiquitin stress does not upregulate proteasome abundance. Instead, ubiquitin stress alters proteasome composition. The proteasome-associated deubiquitinating enzyme Ubp6, which spares ubiquitin from proteasomal degradation, is induced by ubiquitin deficiency. This enhances loading of proteasomes with Ubp6, thereby altering proteasome function. A catalytically inactive mutant of Ubp6 fails to recycle ubiquitin and also inhibits proteasome function directly, thus inducing both ubiquitin stress and proteasome stress. These results show that homeostatic control of the ubiquitin-proteasome pathway can be achieved through signal-dependent, subunit-specific regulation of the proteasome, and indicate a dual role of Ubp6 in regulating ubiquitin levels and proteasome function.

A ubiquitin stress response induces altered proteasome composition. Publishing Authors By Initials

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

PUBMED ID PMID:

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A ubiquitin stress response induces altered proteasome composition. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cell

VOLUME: 129

Page Numbers: 747-59

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 18

MONTH: May

YEAR: 2007

A ubiquitin stress response induces altered proteasome composition. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413066

A ubiquitin stress response induces altered proteasome composition. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: physiology

Chemical & Substance for Abstract: A ubiquitin stress response induces altered proteasome composition. Information

Substance Name: UBP6 protein, S cerevisiae

Registry Number: EC 3.4.99.-

Grant and Affiliation Information for A ubiquitin stress response induces altered proteasome composition.

AFFILIATION: Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM65592

ACRONYM: GM

MEDLINETA: Cell

REFSOURCE: Cell. 2007 May 18;129(4):659-62

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