A triazolam/amphetamine dose-effect interaction study: dissociation of effects on memory versus arousal.

A triazolam/amphetamine dose-effect interaction study: dissociation of effects on memory versus arousal. Research Abstract Details 

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A triazolam/amphetamine dose-effect interaction study: dissociation of effects on memory versus arousal. Abstract Text:

Miriam Z Mintzer,Roland R Griffiths,

RATIONALE: In addition to producing robust memory impairment, benzodiazepines also induce marked sedation. Thus, it is possible that the observed amnestic effects are secondary to more global sedative effects and do not reflect a specific primary benzodiazepine effect on memory mechanisms. OBJECTIVE: The objective was to use the nonspecific stimulant d-amphetamine to dissociate the sedative and memory-impairing effects of the benzodiazepine triazolam. MATERIALS AND METHODS: Single oral doses of placebo, triazolam alone (0.25, 0.50 mg/70 kg), d-amphetamine sulfate alone (20, 30 mg/70 kg), and triazolam (0.25, 0.50 mg/70 kg) and d-amphetamine sulfate (20, 30 mg/70 kg) conjointly (at all dose combinations) were administered to 18 healthy adult participants across nine sessions in a double-blind, staggered-dosing, crossover design. In addition to standard data analyses, analyses were also conducted on z-score standardized data, enabling effects to be directly compared across measures. RESULTS: Relative to the sedative measures, the memory measures generally exhibited a pattern of less reversal of triazolam's effects by d-amphetamine. The memory measures ranged in degree of reversal such that the most reversal was observed for reaction time on the n-back working memory task, and the least reversal was observed for accuracy on the Sternberg working memory task, with most measures showing an overall pattern of partial reversal. CONCLUSIONS: Benzodiazepines have specific effects on memory that are not merely a by-product of the drugs' sedative effects, and the degree to which sedative effects contribute to the amnestic effects varies as a function of the particular memory process being assessed.

A triazolam/amphetamine dose-effect interaction study: dissociation of effects on memory versus arousal. Publishing Authors By Initials

MZ Mintzer,RR Griffiths,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzazepines: benzodiazepines: triazolam research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzazepines: benzodiazepines: triazolam research

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MEDLINE DATE:

A triazolam/amphetamine dose-effect interaction study: dissociation of effects on memory versus arousal. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Psychopharmacology

VOLUME: 192

Page Numbers: 425-40

Journal Abbreviation:

ISSN: 0033-3158

DAY: 7

MONTH: 03

YEAR: 2007

A triazolam/amphetamine dose-effect interaction study: dissociation of effects on memory versus arousal. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7608025

A triazolam/amphetamine dose-effect interaction study: dissociation of effects on memory versus arousal. Keywords Mesh Terms:

KEYWORDS: Triazolam

MESH TERMS: pharmacology

Chemical & Substance for Abstract: A triazolam/amphetamine dose-effect interaction study: dissociation of effects on memory versus arousal. Information

Substance Name: Dextroamphetamine

Registry Number: 51-64-9

Grant and Affiliation Information for A triazolam/amphetamine dose-effect interaction study: dissociation of effects on memory versus arousal.

AFFILIATION: Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. mmintzer@jhmi.edu

Country: Germany

AGENCY: United States NIDA

GRANT: DA-11936

ACRONYM: DA

MEDLINETA: Psychopharmacology (Berl)

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