A theoretical model for F-actin remodeling in vascular smooth muscle cells subjected to cyclic stretch.

A theoretical model for F-actin remodeling in vascular smooth muscle cells subjected to cyclic stretch. Research Abstract Details 

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A theoretical model for F-actin remodeling in vascular smooth muscle cells subjected to cyclic stretch. Abstract Text:

S Na,G A Meininger,J D Humphrey,

A constrained mixture theory model was developed and used to estimate remodeling of F-actin in vascular smooth muscle cells that were subjected to 10% equibiaxial stretching for up to 30min. The model was based on a synthesis of data on time-dependent changes in atomic force microscopy measured cell stiffness and immunofluorescence measured focal adhesion associated vinculin as well as data on stress fiber stiffness and pre-stretch. Results suggest that an observed acute (after 2min of stretching) increase in cell stiffness is consistent with an increased stretch of the originally present F-actin plus an assembly of new F-actin having nearly homeostatic values of stretch. Moreover, the subsequent (after 30min of stretching) decrease in cell stiffness back towards the baseline value is consistent with a replacement of the overstretched original filaments with the new (reassembled), less stretched filaments. That is, overall cell response is consistent with a recently proposed concept of "tensional homeostasis" whereby cells seek to maintain constant certain mechanical factors via a remodeling of intracellular and transmembrane proteins. Although there is a need to refine the model based on more comprehensive data sets, using multiple experimental approaches, the present results suggest that a constrained mixture theory can capture salient features of the dynamics of F-actin remodeling and that it offers some advantages over many past methods of modeling, particularly those based on classical linearized viscoelasticity.

A theoretical model for F-actin remodeling in vascular smooth muscle cells subjected to cyclic stretch. Publishing Authors By Initials

S Na,GA Meininger,JD Humphrey,

For similar proteins: cytoskeletal proteins: vinculin research abstracts see: proteins: cytoskeletal proteins: vinculin research

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A theoretical model for F-actin remodeling in vascular smooth muscle cells subjected to cyclic stretch. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of theoretical biology

VOLUME: 246

Page Numbers: 87-99

Journal Abbreviation:

ISSN: 0022-5193

DAY: 15

MONTH: 12

YEAR: 2006

A theoretical model for F-actin remodeling in vascular smooth muscle cells subjected to cyclic stretch. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376342

A theoretical model for F-actin remodeling in vascular smooth muscle cells subjected to cyclic stretch. Keywords Mesh Terms:

KEYWORDS: Vinculin

MESH TERMS: physiology

Chemical & Substance for Abstract: A theoretical model for F-actin remodeling in vascular smooth muscle cells subjected to cyclic stretch. Information

Substance Name: Vinculin

Registry Number: 125361-02-6

Grant and Affiliation Information for A theoretical model for F-actin remodeling in vascular smooth muscle cells subjected to cyclic stretch.

AFFILIATION: Department of Biomedical Engineering and M.E. DeBakey Institute, Texas A&M University, College Station, TX 77843, USA.

Country: Netherlands

AGENCY: United States NHLBI

GRANT: R21 HL076319-02

ACRONYM: HL

MEDLINETA: J Theor Biol

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