A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling.

A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. Research Abstract Details 

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A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. Abstract Text:

Kimberly A Brown,Jennifer A Pietenpol,Harold L Moses,

Transforming growth factor-beta (TGF-beta) is an important growth inhibitor of epithelial cells, and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. Smad2 and Smad3 are direct mediators of TGF-beta signaling, however little is known about the selective activation of Smad2 versus Smad3. The Smad2 and Smad3 knockout mouse phenotypes and studies comparing Smad2 and Smad3 activation of TGF-beta target genes, suggest that Smad2 and Smad3 have distinct roles in TGF-beta signaling. The observation that TGF-beta inhibits proliferation of Smad3-null mammary gland epithelial cells, whereas Smad3 deficient fibroblasts are only partially growth inhibited, suggests that Smad3 has a different role in epithelial cells and fibroblasts. Herein, the current understanding of Smad2 and Smad3-mediated TGF-beta signaling and their relative roles are discussed, in addition to potential mechanisms for the selective activation of Smad2 versus Smad3. Since alterations in the TGF-beta signaling pathway play an important role in promoting tumorigenesis and cancer progression, methods for therapeutic targeting of the TGF-beta signaling pathway are being pursued. Determining how Smad2 or Smad3 differentially regulate the TGF-beta response may translate into developing more effective strategies for cancer therapy.

A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. Publishing Authors By Initials

KA Brown,JA Pietenpol,HL Moses,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of cellular biochemistry

VOLUME: 101

Page Numbers: 9-33

Journal Abbreviation:

ISSN: 0730-2312

DAY: 1

MONTH: May

YEAR: 2007

A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. Information

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LANGUAGE: eng

NlmUniqueID: 8205768

A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: metabolism

Chemical & Substance for Abstract: A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. Information

Substance Name: Transforming Growth Factor beta

Registry Number: 0

Grant and Affiliation Information for A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling.

AFFILIATION: Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA102162

ACRONYM: CA

MEDLINETA: J Cell Biochem

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