A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major.

A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major. Research Abstract Details 

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A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major. Abstract Text:

Wing-Yan Au,Wynnie Wai-Man Lam,Winnie Chu,Sidney Tam,Wai-Keng Wong,Raymond Liang,Shau-Yin Ha,

We studied the utility of pancreatic magnetic resonance imaging (MRI) in 72 thalassemia major patients (21 diabetic, 51 normoglycemic). Diabetic patients were significantly older (p<0.0001) and had smaller pancreas volume (p<0.0001). The two groups were comparable for ferritin and MRI-T2* heart, liver and pancreas. Pancreatic T2* signals were abnormal in 80% of both groups, and correlated with heart T2*. In normoglycemic patients, cardiac T2* and log-pancreatic T2* values correlated with homeostatic model assessments HOMA-B (beta cell reserve), HOMA-IR (insulin resistance) and fasting insulin/C-peptide levels. This suggested that improved chelation may improve beta cell reserve and prevent pancreatic atrophy.

A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major. Publishing Authors By Initials

WY Au,WW Lam,W Chu,S Tam,WK Wong,R Liang,SY Ha,

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A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Haematologica

VOLUME: 93

Page Numbers: 116-9

Journal Abbreviation: Haematologica

ISSN: 1592-8721

DAY: 1

MONTH: Jan

YEAR: 2008

A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major. Information

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LANGUAGE: eng

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AFFILIATION: Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China. auwing@hotmail.com

Country: Italy

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MEDLINETA: Haematologica

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