A systematic review of treatment modalities for primary basal cell carcinomas.

A systematic review of treatment modalities for primary basal cell carcinomas. Research Abstract Details 

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A systematic review of treatment modalities for primary basal cell carcinomas. Abstract Text:

OBJECTIVE: To systematically review the literature for studies reporting on recurrence rates of basal cell carcinomas (BCCs) after different therapies. DESIGN: We reviewed all studies published in English, French, German, Dutch, Spanish, or Italian between 1970 and 1997 that prospectively examined recurrence rates for at least 50 patients with primary BCCs observed for at least 5 years after treatment with Mohs micrographic surgery, surgical excision, curettage and electrodesiccation, cryosurgery, radiotherapy, immunotherapy with interferon or fluorouracil, or photodynamic therapy. SETTING: Department of Dermatology, University Hospital Maastricht, Maastricht, the reference center for dermatologic oncology and Mohs micrographic surgery in the Netherlands. MAIN OUTCOME MEASURES: The recurrence rates after different therapies for BCCs, resulting in the development of guidelines for the treatment of these disorders. RESULTS: Of 298 studies found in several electronic databases, only 18 met the requirements and could be used for analysis. Tumors treated with Mohs micrographic surgery show the lowest recurrence rates after 5 years, followed in order by those treated with surgical excision, cryosurgery, and curettage and electrodesiccation. CONCLUSIONS: Recurrence rates for different therapies could not be compared because of a lack of uniformity in the method of reporting, so evidence-based guidelines could not be developed. We surmise that Mohs micrographic surgery should be used mainly for larger, morphea-type BCCs located in danger zones. For smaller BCCs of the nodular and superficial types, surgical excision remains the first treatment of choice. Other treatment modalities can be used in patients in whom surgery is contraindicated. Immunotherapy and photodynamic therapy are still investigative.

A systematic review of treatment modalities for primary basal cell carcinomas. Publishing Authors By Initials

For similar neoplasms: neoplasms by site: skin neoplasms research abstracts see: neoplasms: neoplasms by site: skin neoplasms research

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A systematic review of treatment modalities for primary basal cell carcinomas. Journal Published:

PUBLICATION TYPE: Review

Journal: Archives of dermatology

VOLUME: 135

Page Numbers: 1177-83

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Oct

YEAR: 1999

A systematic review of treatment modalities for primary basal cell carcinomas. Information

Number of References: 66

LANGUAGE: eng

NlmUniqueID: 372433

A systematic review of treatment modalities for primary basal cell carcinomas. Keywords Mesh Terms:

KEYWORDS: Skin Neoplasms

MESH TERMS: therapy

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Grant and Affiliation Information for A systematic review of treatment modalities for primary basal cell carcinomas.

AFFILIATION: Department of Dermatology, University of Maastricht Medical Center, The Netherlands.

Country: UNITED STATES

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MEDLINETA: Arch Dermatol

REFSOURCE: Arch Dermatol. 2000 Jun;136(6):800

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