A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila.

A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila. Research Abstract Details 

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A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila. Abstract Text:

Chun-Hong Chen,Haixia Huang,Catherine M Ward,Jessica T Su,Lorian V Schaeffer,Ming Guo,Bruce A Hay,

One proposed strategy for controlling the transmission of insect-borne pathogens uses a drive mechanism to ensure the rapid spread of transgenes conferring disease refractoriness throughout wild populations. Here, we report the creation of maternal-effect selfish genetic elements in Drosophila that drive population replacement and are resistant to recombination-mediated dissociation of drive and disease refractoriness functions. These selfish elements use microRNA-mediated silencing of a maternally expressed gene essential for embryogenesis, which is coupled with early zygotic expression of a rescuing transgene.

A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila. Publishing Authors By Initials

CH Chen,H Huang,CM Ward,JT Su,LV Schaeffer,M Guo,BA Hay,

For similar urogenital system: genitalia: germ cells: ovum: zygote research abstracts see: urogenital system: genitalia: germ cells: ovum: zygote research

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A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Science (New York, N.Y.)

VOLUME: 316

Page Numbers: 597-600

Journal Abbreviation:

ISSN: 1095-9203

DAY: 29

MONTH: 03

YEAR: 2007

A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 404511

A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila. Keywords Mesh Terms:

KEYWORDS: Zygote

MESH TERMS: physiology

Chemical & Substance for Abstract: A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila. Information

Substance Name: Receptors, Immunologic

Registry Number: 0

Grant and Affiliation Information for A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila.

AFFILIATION: Division of Biology, Mail Code 156-29, California Institute of Technology, Pasadena, CA 91125, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS048396

ACRONYM: NS

MEDLINETA: Science

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