A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy entropy compensation.

A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy entropy compensation. Research Abstract Details 

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A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy entropy compensation. Abstract Text:

Mikhail V Rekharsky,Tadashi Mori,Cheng Yang,Young Ho Ko,N Selvapalam,Hyunuk Kim,David Sobransingh,Angel E Kaifer,Simin Liu,Lyle Isaacs,Wei Chen,Sarvin Moghaddam,Michael K Gilson,Kimoon Kim,Yoshihisa Inoue,Mikhail V Rekharsky,Tadashi Mori,Cheng Yang,Young Ho Ko,N Selvapalam,Hyunuk Kim,David Sobransingh,Angel E Kaifer,Simin Liu,Lyle Isaacs,Wei Chen,Sarvin Moghaddam,Michael K Gilson,Kimoon Kim,Yoshihisa Inoue,Mikhail V Rekharsky,Tadashi Mori,Cheng Yang,Young Ho Ko,N Selvapalam,Hyunuk Kim,David Sobransingh,Angel E Kaifer,Simin Liu,Lyle Isaacs,Wei Chen,Sarvin Moghaddam,Michael K Gilson,Kimoon Kim,Yoshihisa Inoue,

The molecular host cucurbit[7]uril forms an extremely stable inclusion complex with the dicationic ferrocene derivative bis(trimethylammoniomethyl)ferrocene in aqueous solution. The equilibrium association constant for this host-guest pair is 3 x 10(15) M(-1) (K(d) = 3 x 10(-16) M), equivalent to that exhibited by the avidin-biotin pair. Although purely synthetic systems with larger association constants have been reported, the present one is unique because it does not rely on polyvalency. Instead, it achieves its extreme affinity by overcoming the compensatory enthalpy-entropy relationship usually observed in supramolecular complexes. Its disproportionately low entropic cost is traced to extensive host desolvation and to the rigidity of both the host and the guest.

A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy entropy compensation. Publishing Authors By Initials

MV Rekharsky,T Mori,C Yang,YH Ko,N Selvapalam,H Kim,D Sobransingh,AE Kaifer,S Liu,L Isaacs,W Chen,S Moghaddam,MK Gilson,K Kim,Y Inoue,MV Rekharsky,T Mori,C Yang,YH Ko,N Selvapalam,H Kim,D Sobransingh,AE Kaifer,S Liu,L Isaacs,W Chen,S Moghaddam,MK Gilson,K Kim,Y Inoue,MV Rekharsky,T Mori,C Yang,YH Ko,N Selvapalam,H Kim,D Sobransingh,AE Kaifer,S Liu,L Isaacs,W Chen,S Moghaddam,MK Gilson,K Kim,Y Inoue,

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A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy entropy compensation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 20737-42

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 1091-6490

DAY: 19

MONTH: 12

YEAR: 2007

A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy entropy compensation. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy entropy compensation.

AFFILIATION: ICORP Entropy Control Project (JST) and Department of Applied Chemistry, Osaka University, Yamada-oka, Suita 565-0871, Japan.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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