A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide.

A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide. Research Abstract Details 

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A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide. Abstract Text:

Daniela Arosio,Marco Fontanella,Laura Baldini,Laura Mauri,Anna Bernardi,Alessandro Casnati,Francesco Sansone,Rocco Ungaro,

A high-affinity ligand of cholera toxin, the divalent glycocalix[4]arene 1, was obtained by exploiting a combination of structure-based design of glycomimetic monovalent ligands and affinity enhancements by multivalent presentation through a calix[4]arene scaffold. It exhibits a slightly higher affinity for the toxin than its natural ligand, the GM1 oligosaccharide.

A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide. Publishing Authors By Initials

D Arosio,M Fontanella,L Baldini,L Mauri,A Bernardi,A Casnati,F Sansone,R Ungaro,

For similar organic chemicals: phenols research abstracts see: organic chemicals: phenols research

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A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 3660-1

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 23

MONTH: Mar

YEAR: 2005

A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide. Keywords Mesh Terms:

KEYWORDS: Phenols

MESH TERMS: metabolism

Chemical & Substance for Abstract: A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide. Information

Substance Name: Cholera Toxin

Registry Number: 9012-63-9

Grant and Affiliation Information for A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide.

AFFILIATION: Università di Milano, Dipartimento di Chimica Organica e Industriale and Centro di Eccellenza CISI, via Venezian 21, 20133 Milano, Italy.

Country: United States

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MEDLINETA: J Am Chem Soc

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