A subset of equine sarcoids harbours BPV-1 DNA in a complex with L1 major capsid protein.

A subset of equine sarcoids harbours BPV-1 DNA in a complex with L1 major capsid protein. Research Abstract Details 

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A subset of equine sarcoids harbours BPV-1 DNA in a complex with L1 major capsid protein. Abstract Text:

Bovine papillomavirus type 1 or 2 (BPV-1, BPV-2) are accepted causal factors in equine sarcoid pathogenesis. Whereas viral genomes are consistently found and expressed within lesions, intact virions have never been detected, thus permissiveness of sarcoids for BPV-1 replication remains unclear. To reassess this issue, an immunocapture PCR (IC/PCR) was established using L1-specific antibodies to capture L1-DNA complexes followed by amplification of the viral genome. Following validation of the assay, 13 sarcoid-bearing horses were evaluated by IC/PCR. Samples were derived from 21 tumours, 4 perilesional/intact skin biopsies, and 1 serum. Tissue extracts from sarcoid-free equines served as controls. IC/PCR scored positive in 14/24 (58.3%) specimens obtained from sarcoid-patients, but negative for controls. Quantitative IC/PCR demonstrated <125 immunoprecipitable viral genomes/50 microl extract for the majority of specimens. Moreover, full-length BPV-1 genomes were detected in a complex with L1 proteins. These complexes may correspond to virion precursors or intact virions.

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A subset of equine sarcoids harbours BPV-1 DNA in a complex with L1 major capsid protein. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virology

VOLUME: 375

Page Numbers: 433-41

Journal Abbreviation: Virology

ISSN: 0042-6822

DAY: 18

MONTH: 04

YEAR: 2008

A subset of equine sarcoids harbours BPV-1 DNA in a complex with L1 major capsid protein. Information

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LANGUAGE: eng

NlmUniqueID: 110674

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Grant and Affiliation Information for A subset of equine sarcoids harbours BPV-1 DNA in a complex with L1 major capsid protein.

AFFILIATION: Equine Biotechnology Unit (EBU), Equine Centre, Veterinary University Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.

Country: United States

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MEDLINETA: Virology

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