A subset of CD4+ thymocytes selected by MHC class I molecules.

A subset of CD4+ thymocytes selected by MHC class I molecules. Research Abstract Details 

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A subset of CD4+ thymocytes selected by MHC class I molecules. Abstract Text:

To complete their maturation, most immature thymocytes depend on the simultaneous engagement of their antigen receptor [alpha beta T cell receptor (TCR)] and their CD4 or CD8 coreceptors with major histocompatibility complex class II or I ligands, respectively. However, a normal subset of mature alpha beta TCR+ thymocytes did not follow these rules. These thymocytes expressed NK1.1 and a restricted set of alpha beta TCRs that are intrinsically class I-reactive because their positive selection was class I-dependent but CD8-independent. These cells were CD4+ and CD4-8- but never CD8+, because the presence of CD8 caused negative selection. Thus, neither CD4 nor CD8 contributes signals that direct their maturation into the CD4+ and CD4-8- lineages.

A subset of CD4+ thymocytes selected by MHC class I molecules. Publishing Authors By Initials

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research

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A subset of CD4+ thymocytes selected by MHC class I molecules. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Science (New York, N.Y.)

VOLUME: 263

Page Numbers: 1774-8

Journal Abbreviation: Science

ISSN: 0036-8075

DAY: 25

MONTH: Mar

YEAR: 1994

A subset of CD4+ thymocytes selected by MHC class I molecules. Information

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LANGUAGE: eng

NlmUniqueID: 404511

A subset of CD4+ thymocytes selected by MHC class I molecules. Keywords Mesh Terms:

KEYWORDS: T-Lymphocyte Subsets

MESH TERMS: immunology

Chemical & Substance for Abstract: A subset of CD4+ thymocytes selected by MHC class I molecules. Information

Substance Name: Killer Cell Lectin-Like Receptor Subfami

Registry Number: 145113-62-8

Grant and Affiliation Information for A subset of CD4+ thymocytes selected by MHC class I molecules.

AFFILIATION: Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Country: UNITED STATES

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MEDLINETA: Science

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