[A study on the adduct characteristics of styrene and DNA]

[A study on the adduct characteristics of styrene and DNA] Research Abstract Details 

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[A study on the adduct characteristics of styrene and DNA] Abstract Text:

Hua Shao,Jie Li,Yikang Shi,

OBJECTIVE: To explore the adduct characteristics of styrene and DNA. METHODS: The adduct reactions between styrene, urinary mandalic acid(MA), phenylglyoxalic acid(PGA), mercapturic acid of styrene (UMA) and DNA were studied by ultraviolet spectral analysis. The SO-DNA adducts by 32P-post labeled method, the chemical structures of SO-DNA adducts by GC-MS and NMR were also studied. RESULTS: SO combined with DNA at O6, N2 positions of dGMP to form six adducts, but styrene, urinary mandalic acid, phenylglyoxalic acid and mercapturic acid of styrene did not react with DNA to form adduct. CONCLUSIONS: Styrene formed adduct with DNA through its active center metabolite--SO after entering the body. SO combined with DNA at O6, N2 positions of dGMP to form adducts. If these DNA adducts are not repaired or are mis-repaired before cell duplication, the gene mutation and chemical damage would happen. No adduct reactions are seen among other metabolites of styrene.

[A study on the adduct characteristics of styrene and DNA] Publishing Authors By Initials

H Shao,J Li,Y Shi,

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[A study on the adduct characteristics of styrene and DNA] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Z

VOLUME: 20

Page Numbers: 347-9

Journal Abbreviation: Zhonghua Lao Dong Wei Sheng Zh

ISSN: 1001-9391

DAY: 25

MONTH: Oct

YEAR: 2002

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LANGUAGE: chi

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AFFILIATION: Shandong Institute of Labor Health and Occupational Disease, Jinan, Shandon 250062, China.

Country: China

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MEDLINETA: Zhonghua Lao Dong Wei Sheng Zh

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