A study of the calcium complex of a glucosylceramide, soya-cerebroside II.

A study of the calcium complex of a glucosylceramide, soya-cerebroside II. Research Abstract Details 

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A study of the calcium complex of a glucosylceramide, soya-cerebroside II. Abstract Text:

Michio Kurosu,Seiji Katayama,Hirotaka Shibuya,Isao Kitagawa,Michio Kurosu,Seiji Katayama,Hirotaka Shibuya,Isao Kitagawa,Michio Kurosu,Seiji Katayama,Hirotaka Shibuya,Isao Kitagawa,

In order to study calcium ion complex of soya-cerebroside II (1), an ionophoretic glucosylceramide isolated from soybean, C8-cerebroside (3) and 3,3'',6''-trideoxy-C8-cerebroside (4) are designed and synthesized. On the basis of extensive 1H-NMR studies in the presence of Ca2+ and a continuous variation method via (1)H-NMR, soya-cerebroside II is suggested to form a calcium complex with 1/Ca2+ ratio of 1 : 1. Soya-cerebroside II serves as a tridentate chelating ligand for Ca2+; the amide carbonyl, C2'-hydroxy, and C2''-hydroxy oxygens are responsible for the Ca2+ binding. Soya-cerebroside II is structurally analogous to a neural glucosylceramide. Thus, the accumulated neural glucosylceramide inside of endoplasmic reticulum (ER) membrane may serve as an endogenous Ca2+-binding and -transport molecule (ionophore) that result in mobilization of Ca2+ from intracellular calcium stores.

A study of the calcium complex of a glucosylceramide, soya-cerebroside II. Publishing Authors By Initials

M Kurosu,S Katayama,H Shibuya,I Kitagawa,M Kurosu,S Katayama,H Shibuya,I Kitagawa,M Kurosu,S Katayama,H Shibuya,I Kitagawa,

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A study of the calcium complex of a glucosylceramide, soya-cerebroside II. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Chemical & pharmaceutical bulletin

VOLUME: 55

Page Numbers: 1758-61

Journal Abbreviation: Chem. Pharm. Bull.

ISSN: 0009-2363

DAY: 6

MONTH: Dec

YEAR: 2007

A study of the calcium complex of a glucosylceramide, soya-cerebroside II. Information

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LANGUAGE: eng

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AFFILIATION: Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 1682 Campus Delivery, Fort Coliins, CO 80523-1682, USA. michio.kurosu@colostate.edu

Country: Japan

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MEDLINETA: Chem Pharm Bull (Tokyo)

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