A study of silica nephrotoxicity in exposed silicotic and non-silicotic workers.

A study of silica nephrotoxicity in exposed silicotic and non-silicotic workers. Research Abstract Details 

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A study of silica nephrotoxicity in exposed silicotic and non-silicotic workers. Abstract Text:

The possible human nephrotoxicity of silica has often been suggested by previous anecdotal reports and uncontrolled clinical studies of silicotic patients. Urinary excretions of albumin, alpha-1-microglobulin (AMG), and beta-N-acetyl-glucosaminidase (NAG) were measured in 33 male workers exposed to silica (mean duration of employment 16 years) and 19 male age matched non-exposed subjects with no history of primary or secondary renal diseases. Significantly higher urinary excretions of albumin and AMG were found in the workers exposed to silica. Silicotic subjects (n = 7) also had significantly high excretions of albumin, AMG, and NAG. All but one of the silicotic patients had ceased exposure from three to 17 years before the study. Our findings suggest that prolonged exposure to silica is associated with chronic irreversible nephrotoxicity in exposed workers.

A study of silica nephrotoxicity in exposed silicotic and non-silicotic workers. Publishing Authors By Initials

For similar inorganic chemicals: minerals: silicon dioxide research abstracts see: inorganic chemicals: minerals: silicon dioxide research

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A study of silica nephrotoxicity in exposed silicotic and non-silicotic workers. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: British journal of industrial medicine

VOLUME: 49

Page Numbers: 35-7

Journal Abbreviation: Br J Ind Med

ISSN: 0007-1072

DAY: 28

MONTH: Jan

YEAR: 1992

A study of silica nephrotoxicity in exposed silicotic and non-silicotic workers. Information

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LANGUAGE: eng

NlmUniqueID: 370637

A study of silica nephrotoxicity in exposed silicotic and non-silicotic workers. Keywords Mesh Terms:

KEYWORDS: Silicon Dioxide

MESH TERMS: adverse effects

Chemical & Substance for Abstract: A study of silica nephrotoxicity in exposed silicotic and non-silicotic workers. Information

Substance Name: Acetylglucosaminidase

Registry Number: EC 3.2.1.52

Grant and Affiliation Information for A study of silica nephrotoxicity in exposed silicotic and non-silicotic workers.

AFFILIATION: Department of Community, Occupational, and Family Medicine, National University of Singapore.

Country: ENGLAND

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MEDLINETA: Br J Ind Med

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