[A study of association between atherothrombotic brain infarction and HLA-DQA1 peptide binding motifs]

[A study of association between atherothrombotic brain infarction and HLA-DQA1 peptide binding motifs] Research Abstract Details 

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[A study of association between atherothrombotic brain infarction and HLA-DQA1 peptide binding motifs] Abstract Text:

N Shen,Z Yan,P He,Y Jin,S Wang,

OBJECTIVE: To analyze the hereditary susceptibility for HLA-DQA1 alleles according to trait of multiple genes leading to disease in atherothrombotic brain infarction (ABI). METHODS: HLA-DQA1 alleles in ABI patients (n=81) and healthy controls (n=99) were detected by PCR-SSP techniques. RESULTS: (1)The frequency of HLA-DQA1*0301 was significantly higher in ABI patients. (2)The frequency of HLA-DQA1*0301 was significantly higher in patients with family history of essential hypertension (EH). (3)The frequency of HLA-DQA1*0103 was significantly lower in ABI patients. CONCLUSION: HLA-DQA1*0301 allele might be a correlative gene with hereditary susceptibility of ABI and HLA-DQA1*0301 allele might be a correlative gene in ABI patients with the family history of essential hypertension, whereas HLA-DQA1*0103 allele might be a protective gene in the patients with ABI.

[A study of association between atherothrombotic brain infarction and HLA-DQA1 peptide binding motifs] Publishing Authors By Initials

N Shen,Z Yan,P He,Y Jin,S Wang,

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[A study of association between atherothrombotic brain infarction and HLA-DQA1 peptide binding motifs] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yix

VOLUME: 18

Page Numbers: 272-5

Journal Abbreviation: Zhonghua Yi Xue Yi Chuan Xue Z

ISSN: 1003-9406

DAY: 2

MONTH: Aug

YEAR: 2001

[A study of association between atherothrombotic brain infarction and HLA-DQA1 peptide binding motifs] Information

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LANGUAGE: chi

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AFFILIATION: Department of Medicine, Hu Guo Si Hospital of Traditional Chinese Medicine Affliated to Beijing Traditional Chinese Medicine and Materia Medical University,Beijing 100035 P.R.China.

Country: China

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MEDLINETA: Zhonghua Yi Xue Yi Chuan Xue Z

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