A structural perspective on copper uptake in eukaryotes.

A structural perspective on copper uptake in eukaryotes. Research Abstract Details 

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A structural perspective on copper uptake in eukaryotes. Abstract Text:

Christopher J De Feo,Stephen G Aller,Vinzenz M Unger,

Over a decade ago, genetic studies identified a family of small integral membrane proteins, commonly referred to as copper transporters (CTRs) that are both required and sufficient for cellular copper uptake in a yeast genetic complementation assay. We recently used electron crystallography to determine a projection density map of the human high affinity transporter hCTR1 embedded into a lipid bilayer. At 6 A resolution, this first glimpse of the structure revealed that hCTR1 is trimeric and possesses the type of radial symmetry that traditionally has been associated with the structure of certain ion channels such as potassium or gap junction channels. Representative for this particular type of architecture, a region of low protein density at the center of the trimer is consistent with the existence of a copper permeable pore along the center three-fold axis of the trimer. In this contribution, we will briefly discuss how recent structure-function studies correlate with the projection density map, and provide a perspective with respect to the cellular uptake of other transition metals.

A structural perspective on copper uptake in eukaryotes. Publishing Authors By Initials

CJ De Feo,SG Aller,VM Unger,

For similar investigative techniques: genetic techniques: sequence alignment research abstracts see: investigative techniques: genetic techniques: sequence alignment research

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A structural perspective on copper uptake in eukaryotes. Journal Published:

PUBLICATION TYPE: Review

Journal: Biometals : an international journal on the role o

VOLUME: 20

Page Numbers: 705-16

Journal Abbreviation: Biometals

ISSN: 0966-0844

DAY: 9

MONTH: 01

YEAR: 2007

A structural perspective on copper uptake in eukaryotes. Information

Number of References: 64

LANGUAGE: eng

NlmUniqueID: 9208478

A structural perspective on copper uptake in eukaryotes. Keywords Mesh Terms:

KEYWORDS: Sequence Alignment

MESH TERMS: metabolism

Chemical & Substance for Abstract: A structural perspective on copper uptake in eukaryotes. Information

Substance Name: Copper

Registry Number: 7440-50-8

Grant and Affiliation Information for A structural perspective on copper uptake in eukaryotes.

AFFILIATION: Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, P.O. Box 208024, New Haven, CT 06520-8024, USA.

Country: Netherlands

AGENCY: United States NCRR

GRANT: P42 RR-01081

ACRONYM: RR

MEDLINETA: Biometals

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