A strong positive dendritic effect in a peptide dendrimer-catalyzed ester hydrolysis reaction.

A strong positive dendritic effect in a peptide dendrimer-catalyzed ester hydrolysis reaction. Research Abstract Details 

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A strong positive dendritic effect in a peptide dendrimer-catalyzed ester hydrolysis reaction. Abstract Text:

Estelle Delort,Tamis Darbre,Jean-Louis Reymond,

The contribution of the dendritic structure in catalysis of ester hydrolysis was investigated with a systematic peptide dendrimer series of increasing generation number (G1-G4) containing a catalytic consensus sequence His-Ser in all branches. A strong positive dendritic effect was observed with up to 100-fold increased histidine reactivity between G1 and G4. Kinetic studies and isothermal calorimetric titration experiments showed that the strong positive dendritic effect resulted from cooperativity between binding and catalysis.

A strong positive dendritic effect in a peptide dendrimer-catalyzed ester hydrolysis reaction. Publishing Authors By Initials

E Delort,T Darbre,JL Reymond,

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A strong positive dendritic effect in a peptide dendrimer-catalyzed ester hydrolysis reaction. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 15642-3

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 8

MONTH: Dec

YEAR: 2004

A strong positive dendritic effect in a peptide dendrimer-catalyzed ester hydrolysis reaction. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

A strong positive dendritic effect in a peptide dendrimer-catalyzed ester hydrolysis reaction. Keywords Mesh Terms:

KEYWORDS: Peptides

MESH TERMS: chemistry

Chemical & Substance for Abstract: A strong positive dendritic effect in a peptide dendrimer-catalyzed ester hydrolysis reaction. Information

Substance Name: 4-methylimidazole

Registry Number: 822-36-6

Grant and Affiliation Information for A strong positive dendritic effect in a peptide dendrimer-catalyzed ester hydrolysis reaction.

AFFILIATION: Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, 3012 Berne, Switzerland.

Country: United States

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MEDLINETA: J Am Chem Soc

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