A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling.

A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling. Research Abstract Details 

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A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling. Abstract Text:

Jiyoun Lee,Mark J Zylka,David J Anderson,Joanna E Burdette,Teresa K Woodruff,Thomas J Meade,

We have synthesized the first steroid hormone-MR contrast agent conjugate designed to track the cell signaling process upon binding to a gene switch system. The derivative has a high relaxivity and when tested in vitro is active as a progesterone antagonist (RU-486). By combining a transcriptional system and a noninvasive imaging technology, such as MRI, it would be a powerful tool to research the cell signaling pathway in vivo.

A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling. Publishing Authors By Initials

J Lee,MJ Zylka,DJ Anderson,JE Burdette,TK Woodruff,TJ Meade,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 13164-6

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 28

MONTH: Sep

YEAR: 2005

A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: physiology

Chemical & Substance for Abstract: A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling. Information

Substance Name: Mifepristone

Registry Number: 84371-65-3

Grant and Affiliation Information for A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling.

AFFILIATION: Department of Chemistry, Northwestern University, Evanston, Illinois 60201, USA.

Country: United States

AGENCY: United States NICHD

GRANT: T32 HD007068

ACRONYM: HD

MEDLINETA: J Am Chem Soc

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