A statistical phylogeography of influenza A H5N1.

A statistical phylogeography of influenza A H5N1. Research Abstract Details 

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A statistical phylogeography of influenza A H5N1. Abstract Text:

Robert G Wallace,Hoangminh Hodac,Richard H Lathrop,Walter M Fitch,

The geographic diffusion of highly pathogenic influenza A H5N1 has largely been traced from the perspective of the virus's victims. Birds of a variety of avian orders have been sampled across localities, and their infection has been identified by a general genetic test. Another approach tracks the migration from the perspective of the virus alone, by way of a phylogeography of H5N1 genetic sequences. Although several phylogenies in the literature have labeled H5N1 clades by geographic region, none has analytically inferred the history of the virus's migration. With a statistical phylogeography of 192 hemagglutinin and neuraminidase isolates, we show that the Chinese province of Guangdong is the source of multiple H5N1 strains spreading at both regional and international scales. In contrast, Indochina appears to be a regional sink, at the same time demonstrating bidirectional dispersal among localities within the region. An evolutionary trace of HA(1) across the phylogeography suggests a mechanism by which H5N1 is able to infect repeated cycles of host species across localities, regardless of the host species first infected in each locale. The trace also hypothesizes amino acid replacements that preceded the first recorded outbreak of pathogenic H5N1 in Hong Kong, 1997.

A statistical phylogeography of influenza A H5N1. Publishing Authors By Initials

RG Wallace,H Hodac,RH Lathrop,WM Fitch,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: evolution: phylogeny research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: evolution: phylogeny research

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MEDLINE DATE:

A statistical phylogeography of influenza A H5N1. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 4473-8

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 7

MONTH: 03

YEAR: 2007

A statistical phylogeography of influenza A H5N1. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

A statistical phylogeography of influenza A H5N1. Keywords Mesh Terms:

KEYWORDS: Phylogeny

MESH TERMS: epidemiology

Chemical & Substance for Abstract: A statistical phylogeography of influenza A H5N1. Information

Substance Name: Hemagglutinin Glycoproteins, Influenza V

Registry Number: 0

Grant and Affiliation Information for A statistical phylogeography of influenza A H5N1.

AFFILIATION: Department of Ecology and Evolutionary Biology, University of California-Irvine, 321 Steinhaus Hall, Irvine, CA 92697, USA. rwallace@uci.edu

Country: United States

AGENCY: United States NIAID

GRANT: 1R21 AI 063275-01

ACRONYM: AI

MEDLINETA: Proc Natl Acad Sci U S A

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