A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development.

A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development. Research Abstract Details 

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A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development. Abstract Text:

Brian S Snarr,Elaine E Wirrig,Aimee L Phelps,Thomas C Trusk,Andy Wessels,

The mesenchymal tissues involved in cardiac septation are derived from different sources. In addition to endocardial-derived mesenchyme, the heart also receives contributions from the neural crest, the proepicardium, and the dorsal mesenchymal protrusion (DMP). Whereas the contributions of the neural crest and proepicardium have been thoroughly studied, the DMP has received little attention. Here, we present the results of a comprehensive spatiotemporal study of the DMP in cardiac development. Using the Tie2-Cre mouse, immunohistochemistry, and AMIRA reconstructions, we show that the DMP, in combination with the mesenchymal cap on the primary atrial septum, fuse with the major atrioventricular cushions to close the primary atrial foramen and to form the atrioventricular mesenchymal complex. In this complex, the DMP constitutes a discrete prominent mesenchymal component, wedged in between the major cushions. This new model for atrioventricular septation may provide novel insights into understanding the etiology of congenital cardiac malformations.

A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development. Publishing Authors By Initials

BS Snarr,EE Wirrig,AL Phelps,TC Trusk,A Wessels,

For similar reproductive and urinary physiology: reproduction: pregnancy research abstracts see: reproductive and urinary physiology: reproduction: pregnancy research

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A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental dynamics : an official publication o

VOLUME: 236

Page Numbers: 1287-94

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ISSN: 1058-8388

DAY: 3

MONTH: May

YEAR: 2007

A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development. Information

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LANGUAGE: eng

NlmUniqueID: 9201927

A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development. Keywords Mesh Terms:

KEYWORDS: Pregnancy

MESH TERMS: cytology

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Grant and Affiliation Information for A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development.

AFFILIATION: Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: T32 HL07260

ACRONYM: HL

MEDLINETA: Dev Dyn

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