A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.

A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Research Abstract Details 

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A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Abstract Text:

Xu Wu,Sheng Ding,Qiang Ding,Nathanael S Gray,Peter G Schultz,

Purmorphamine, which is a 2,6,9-trisubstituted purine compound, was discovered through cell-based high-throughput screening from a heterocycle combinatorial library. It differentiates multipotent mesenchymal progenitor cells into an osteoblast lineage. It will serve as a unique chemical tool to study the molecular mechanisms of osteogenesis of stem cells and bone development.

A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Publishing Authors By Initials

X Wu,S Ding,Q Ding,NS Gray,PG Schultz,

For similar cells: stem cells research abstracts see: cells: stem cells research

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A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 124

Page Numbers: 14520-1

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 11

MONTH: Dec

YEAR: 2002

A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: enzymology

Chemical & Substance for Abstract: A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Information

Substance Name: Alkaline Phosphatase

Registry Number: EC 3.1.3.1

Grant and Affiliation Information for A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.

AFFILIATION: Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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