A small molecule transcriptional activation domain.

A small molecule transcriptional activation domain. Research Abstract Details 

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A small molecule transcriptional activation domain. Abstract Text:

Aaron R Minter,Brian B Brennan,Anna K Mapp,

Artificial transcriptional activators are excellent tools for studying the mechanistic details of transcriptional regulation. Furthermore, as the correlation between a wide range of human diseases and misregulated transcription becomes increasingly evident, such molecules may in the long run serve as the basis for transcription-based therapeutic agents. The greatest challenge in this arena has been the discovery of organic molecules that are functional mimics of transcriptional activation domains, sequences of natural proteins that participate in a variety of protein-protein interactions to control transcriptional levels. We describe the first examples of small molecules that function in this capacity, isoxazolidines containing an array of polar and hydrophobic functional groups. Despite their small size, the most potent of the structures functions nearly as well as a natural activation domain.

A small molecule transcriptional activation domain. Publishing Authors By Initials

AR Minter,BB Brennan,AK Mapp,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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MEDLINE DATE:

A small molecule transcriptional activation domain. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 10504-5

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 1

MONTH: Sep

YEAR: 2004

A small molecule transcriptional activation domain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

A small molecule transcriptional activation domain. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: A small molecule transcriptional activation domain. Information

Substance Name: common cellular transcription factor ATF

Registry Number: 0

Grant and Affiliation Information for A small molecule transcriptional activation domain.

AFFILIATION: Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM08597

ACRONYM: GM

MEDLINETA: J Am Chem Soc

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