A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study.

A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study. Research Abstract Details 

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A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study. Abstract Text:

Ascan Warnholtz,Mir Abolfazl Ostad,Nathalie Velich,Christine Trautmann,Reinhard Schinzel,Ulrich Walter,Thomas Munzel,Ascan Warnholtz,Mir Abolfazl Ostad,Nathalie Velich,Christine Trautmann,Reinhard Schinzel,Ulrich Walter,Thomas Munzel,

Clinical studies have demonstrated beneficial effects for clopidogrel in patients with atherothrombotic disease. Recent in vitro studies identified stimulating effects of clopidogrel on endothelial cells, pointing towards mechanisms of action beyond the inhibition of platelet aggregation. We hypothesized that in vivo use of clopidogrel improves endothelial dysfunction in patients with coronary artery disease (CAD). Fifty-eight patients with CAD were randomly assigned to double-blinded oral administration of one single dose of clopidogrel 300 mg (C300) or 600 mg (C600), respectively. Endothelial function was assessed by measurement of flow-mediated dilation (FMD) of the brachial artery before and 2, 4 and 22 h after dose administration, respectively. Inhibition of the platelet ADP P2Y12 receptor by clopidogrel was monitored by the ex vivo analysis of ADP effects on prostaglandin-induced platelet VASP phosphorylation. C600 significantly improved FMD at 2, 4 and 22 h, while C300 significantly improved FMD at 4 and 22 h. Clopidogrel dose- and time-dependently inhibited the platelet ADP P2Y12 receptor without correlation with its stimulatory effects on FMD. Our study demonstrates for the first time in vivo that clopidogrel dose-dependently improves endothelial dysfunction. These results may indicate a new and potentially important aspect of the effect of clopidogrel treatment in patients with CAD.

A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study. Publishing Authors By Initials

A Warnholtz,MA Ostad,N Velich,C Trautmann,R Schinzel,U Walter,T Munzel,A Warnholtz,MA Ostad,N Velich,C Trautmann,R Schinzel,U Walter,T Munzel,

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A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Atherosclerosis

VOLUME: 196

Page Numbers: 689-95

Journal Abbreviation: Atherosclerosis

ISSN: 1879-1484

DAY: 9

MONTH: 01

YEAR: 2007

A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study. Information

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LANGUAGE: eng

NlmUniqueID: 242543

A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study. Keywords Mesh Terms:

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Grant and Affiliation Information for A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study.

AFFILIATION: Department of Medicine II, Johannes Gutenberg-University Mainz, Germany. warnholt@uni-mainz.de

Country: Ireland

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MEDLINETA: Atherosclerosis

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