A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation.

A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation. Research Abstract Details 

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A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation. Abstract Text:

Driss Zoukhri,Elizabeth Macari,Claire L Kublin,

Emerging studies from our laboratory demonstrate that interleukin-1 (IL-1) family members play a major role in impairing lacrimal gland functions. Here we have extended our investigations to observe the effects of IL-1 on aqueous tear production, lacrimal gland secretion, lacrimal gland histology, and acinar and ductal cell proliferation. We demonstrate that a single injection of IL-1 into the lacrimal glands inhibited neurally- as well as agonist-induced protein secretion resulting in decreased tear output. Meanwhile, IL-1 injection induced a severe, but reversible (7-13 days), inflammatory response that led to destruction of lacrimal gland acinar epithelial cells. Finally, we demonstrate that as the inflammatory response subsided and lacrimal gland secretion and tear production returned to normal levels, there was increased proliferation of acinar and ductal epithelial cells. Our work uncovers novel effects of IL-1 on lacrimal gland functions and the potential regenerative capacity of the mouse lacrimal gland.

A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation. Publishing Authors By Initials

D Zoukhri,E Macari,CL Kublin,

For similar fluids and secretions: bodily secretions: tears research abstracts see: fluids and secretions: bodily secretions: tears research

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A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Experimental eye research

VOLUME: 84

Page Numbers: 894-904

Journal Abbreviation:

ISSN: 0014-4835

DAY: 4

MONTH: 02

YEAR: 2007

A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation. Information

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LANGUAGE: eng

NlmUniqueID: 370707

A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation. Keywords Mesh Terms:

KEYWORDS: Tears

MESH TERMS: secretion

Chemical & Substance for Abstract: A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation. Information

Substance Name: Peroxidase

Registry Number: EC 1.11.1.7

Grant and Affiliation Information for A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation.

AFFILIATION: Department of General Dentistry, Tufts University School of Dental Medicine, 1 Kneeland Street, DHS834, Boston, MA 02111, USA. driss.zoukhri@tufts.edu

Country: England

AGENCY: United States NEI

GRANT: R01-EY12383

ACRONYM: EY

MEDLINETA: Exp Eye Res

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