A single episode of neonatal seizures permanently alters glutamatergic synapses.

A single episode of neonatal seizures permanently alters glutamatergic synapses. Research Abstract Details 

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A single episode of neonatal seizures permanently alters glutamatergic synapses. Abstract Text:

Brandon J Cornejo,Michael H Mesches,Steven Coultrap,Michael D Browning,Timothy A Benke,

OBJECTIVE: The contribution of seizures to cognitive changes remains controversial. We tested the hypothesis that a single episode of neonatal seizures (sNS) on rat postnatal day (P) 7 permanently impairs hippocampal-dependent function in mature (P60) rats because of long-lasting changes at the synaptic level. METHODS: sNS was induced with subcutaneously injected kainate on P7. Learning, memory, mossy fiber sprouting, spine density, hippocampal synaptic plasticity, and glutamate receptor expression and subcellular distribution were measured at P60. RESULTS: sNS selectively impaired working memory in a hippocampal-dependent radial arm water-maze task without inducing mossy fiber sprouting or altering spine density. sNS impaired CA1 hippocampal long-term potentiation and enhanced long-term depression. Subcellular fractionation and cross-linking, used to determine whether glutamate receptor trafficking underlies the alterations of memory and synaptic plasticity, demonstrated that sNS induced a selective reduction in the membrane pool of glutamate receptor 1 subunits. sNS induced a decrease in the total amount of N-methyl-D-aspartate receptor 2A and an increase in the primary subsynaptic scaffold, PSD-95. INTERPRETATION: These molecular consequences are consistent with the alterations in plasticity and memory caused by sNS at the synaptic level. Our data demonstrate the cognitive impact of sNS and associate memory deficits with specific alterations in glutamatergic synaptic function.

A single episode of neonatal seizures permanently alters glutamatergic synapses. Publishing Authors By Initials

BJ Cornejo,MH Mesches,S Coultrap,MD Browning,TA Benke,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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A single episode of neonatal seizures permanently alters glutamatergic synapses. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Annals of neurology

VOLUME: 61

Page Numbers: 411-26

Journal Abbreviation:

ISSN: 0364-5134

DAY: 3

MONTH: May

YEAR: 2007

A single episode of neonatal seizures permanently alters glutamatergic synapses. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7707449

A single episode of neonatal seizures permanently alters glutamatergic synapses. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: pathology

Chemical & Substance for Abstract: A single episode of neonatal seizures permanently alters glutamatergic synapses. Information

Substance Name: Glutamic Acid

Registry Number: 56-86-0

Grant and Affiliation Information for A single episode of neonatal seizures permanently alters glutamatergic synapses.

AFFILIATION: Department of Pharmacology, University of Colorado, School of Medicine, Denver, CO 80262, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS041267

ACRONYM: NS

MEDLINETA: Ann Neurol

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