A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B.

A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B. Research Abstract Details 

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A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B. Abstract Text:

Kosuke Namba,Hyuk-Sang Jun,Yoshito Kishi,

A simple device consisting of two ion-exchange columns, two alumina-based filters, and a pump (Figure 1) was assembled to form the C8-C14 polycyclic ring system present in the halichondrin B class of marine natural products. The effectiveness of this device was tested for three substrates. In each case, the desired polycyclic ketal 3, 5, or 7 was obtained almost quantitatively in a single operation.

A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B. Publishing Authors By Initials

K Namba,HS Jun,Y Kishi,

For similar natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research abstracts see: natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research

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A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 7770-1

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 30

MONTH: Jun

YEAR: 2004

A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B. Keywords Mesh Terms:

KEYWORDS: Stereoisomerism

MESH TERMS: chemistry

Chemical & Substance for Abstract: A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B. Information

Substance Name: halichondrin B

Registry Number: 103614-76-2

Grant and Affiliation Information for A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B.

AFFILIATION: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA 22215

ACRONYM: CA

MEDLINETA: J Am Chem Soc

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