A serum shock induces circadian gene expression in mammalian tissue culture cells.

A serum shock induces circadian gene expression in mammalian tissue culture cells. Research Abstract Details 

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A serum shock induces circadian gene expression in mammalian tissue culture cells. Abstract Text:

The treatment of cultured rat-1 fibroblasts or H35 hepatoma cells with high concentrations of serum induces the circadian expression of various genes whose transcription also oscillates in living animals. Oscillating genes include rper1 and rper2 (rat homologs of the Drosophila clock gene period), and the genes encoding the transcription factors Rev-Erb alpha, DBP, and TEF. In rat-1 fibroblasts, up to three consecutive daily oscillations with an average period length of 22.5 hr could be recorded. The temporal sequence of the various mRNA accumulation cycles is the same in cultured cells and in vivo. The serum shock of rat-1 fibroblasts also results in a transient stimulation of c-fos and rper expression and thus mimics light-induced immediate-early gene expression in the suprachiasmatic nucleus.

A serum shock induces circadian gene expression in mammalian tissue culture cells. Publishing Authors By Initials

For similar cells: cells, cultured: tumor cells, cultured research abstracts see: cells: cells, cultured: tumor cells, cultured research

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A serum shock induces circadian gene expression in mammalian tissue culture cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell

VOLUME: 93

Page Numbers: 929-37

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 12

MONTH: Jun

YEAR: 1998

A serum shock induces circadian gene expression in mammalian tissue culture cells. Information

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LANGUAGE: eng

NlmUniqueID: 413066

A serum shock induces circadian gene expression in mammalian tissue culture cells. Keywords Mesh Terms:

KEYWORDS: Tumor Cells, Cultured

MESH TERMS: genetics

Chemical & Substance for Abstract: A serum shock induces circadian gene expression in mammalian tissue culture cells. Information

Substance Name: Cycloheximide

Registry Number: 66-81-9

Grant and Affiliation Information for A serum shock induces circadian gene expression in mammalian tissue culture cells.

AFFILIATION: Département de Biologie Moléculaire, Sciences II, Université de Genève, Switzerland.

Country: UNITED STATES

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MEDLINETA: Cell

REFSOURCE: Cell. 1998 Jun 12;93(6):917-9

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