A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus.

A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus. Research Abstract Details 

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A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus. Abstract Text:

Eleusa Maria F Rocha,Guillermo Garcia-Effron,Steven Park,David S Perlin,Eleusa Maria F Rocha,Guillermo Garcia-Effron,Steven Park,David S Perlin,

An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.

A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus. Publishing Authors By Initials

EM Rocha,G Garcia-Effron,S Park,DS Perlin,EM Rocha,G Garcia-Effron,S Park,DS Perlin,

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A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Antimicrobial agents and chemotherapy

VOLUME: 51

Page Numbers: 4174-6

Journal Abbreviation: Antimicrob. Agents Chemother.

ISSN: 0066-4804

DAY: 27

MONTH: 08

YEAR: 2007

A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus. Information

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LANGUAGE: eng

NlmUniqueID: 315061

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Grant and Affiliation Information for A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus.

AFFILIATION: Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI069397

ACRONYM: AI

MEDLINETA: Antimicrob Agents Chemother

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