A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice.

A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Research Abstract Details 

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A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Abstract Text:

Alexander Balbir,Hannah Lee,Mariko Okumura,Shyam Biswal,Robert S Fitzgerald,Machiko Shirahata,

The carotid body (CB) is the primary hypoxic chemosensory organ. Its hypoxic response appears to be genetically controlled. We have hypothesized that: 1) genes related to CB function are expressed less in the A/J mice (low responder to hypoxia) compared with DBA/2J mice (high responder to hypoxia); and 2) gene expression levels of morphogenic and trophic factors of the CB are significantly lower in the A/J mice than DBA/2J mice. This study utilizes microarray analysis to test these hypotheses. Three sets of CBs were harvested from both strains. RNA was isolated and used for global gene expression profiling (Affymetrix Mouse 430 v2.0 array). Statistically significant gene expression was determined as a minimum six counts of nine pairwise comparisons, a minimum 1.5-fold change, and P

A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Publishing Authors By Initials

A Balbir,H Lee,M Okumura,S Biswal,RS Fitzgerald,M Shirahata,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Lung cellular and

VOLUME: 292

Page Numbers: L704-15

Journal Abbreviation: Am. J. Physiol. Lung Cell Mol.

ISSN: 1040-0605

DAY: 10

MONTH: 11

YEAR: 2006

A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Information

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LANGUAGE: eng

NlmUniqueID: 100901229

A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: metabolism

Chemical & Substance for Abstract: A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice.

AFFILIATION: Division of Physiology, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, E7610, 615 N. Wolfe St., Baltimore, MD 21205, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: T32-HL-07534

ACRONYM: HL

MEDLINETA: Am J Physiol Lung Cell Mol Phy

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