A screen for secreted factors of the suprachiasmatic nucleus.

A screen for secreted factors of the suprachiasmatic nucleus. Research Abstract Details 

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A screen for secreted factors of the suprachiasmatic nucleus. Abstract Text:

Achim Kramer,Fu-Chia Yang,Sebastian Kraves,Charles J Weitz,

The circadian clock in the suprachiasmatic nucleus (SCN) drives daily locomotor activity rhythms presumably by secreting diffusible factors whose target sites are accessible from the third ventricle of the hypothalamus. This article describes the methodology of a systematic molecular and behavioral screen to identify "locomotor factors" of the SCN. To find SCN-secreted factors not previously documented, a hamster SCN cDNA library was screened in a yeast signal sequence trap. In a subsequent behavioral screen, newly identified and previously documented SCN factors were tested for an effect on locomotor activity rhythms by chronic infusion into the third ventricle of hamsters. Using this approach combined with further experiments, we identified transforming growth factor-alpha (TGF-alpha) as a likely SCN inhibitor of locomotion.

A screen for secreted factors of the suprachiasmatic nucleus. Publishing Authors By Initials

A Kramer,FC Yang,S Kraves,CJ Weitz,

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A screen for secreted factors of the suprachiasmatic nucleus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Methods in enzymology

VOLUME: 393

Page Numbers: 645-63

Journal Abbreviation: Meth. Enzymol.

ISSN: 0076-6879

DAY: 8

MONTH: 04

YEAR: 2005

A screen for secreted factors of the suprachiasmatic nucleus. Information

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LANGUAGE: eng

NlmUniqueID: 212271

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Country: United States

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MEDLINETA: Methods Enzymol

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