A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease.

A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. Research Abstract Details 

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A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. Abstract Text:

Pu-Ting Xu,Yi-Ju Li,Xue-Jun Qin,Charles Kroner,Anya Green-Odlum,Hong Xu,Tian-Yuan Wang,Donald E Schmechel,Christine M Hulette,John Ervin,Mike Hauser,Jonathan Haines,Margaret A Pericak-Vance,John R Gilbert,Pu-Ting Xu,Yi-Ju Li,Xue-Jun Qin,Charles Kroner,Anya Green-Odlum,Hong Xu,Tian-Yuan Wang,Donald E Schmechel,Christine M Hulette,John Ervin,Mike Hauser,Jonathan Haines,Margaret A Pericak-Vance,John R Gilbert,Pu-Ting Xu,Yi-Ju Li,Xue-Jun Qin,Charles Kroner,Anya Green-Odlum,Hong Xu,Tian-Yuan Wang,Donald E Schmechel,Christine M Hulette,John Ervin,Mike Hauser,Jonathan Haines,Margaret A Pericak-Vance,John R Gilbert,

APOE4 allele is a major risk factor for late-onset Alzheimer disease (AD). The mechanism of action of APOE in AD remains unclear. To study the effects of APOE alleles on gene expression in AD, we have analyzed the gene transcription patterns of human hippocampus from APOE3/3, APOE3/4, APOE4/4 AD patients and normal control using Serial Analysis of Gene Expression (SAGE). Using SAGE, we found gene expression patterns in hippocampus of APOE3/4 and APOE4/4 AD patients differ substantially from those of APOE3/3 AD patients. APOE3/4 and APOE4/4 allele expression may activate similar genes or gene pools with associated functions. APOE4 AD alleles activate multiple tumor suppressors, tumor inducers and negative regulator of cell growth or repressors that may lead to increased cell arrest, senescence and apoptosis. In contrast, there is decreased expression of large clusters of genes associated with synaptic plasticity, synaptic vesicle docking and fusing and axonal/neuronal outgrowth. In addition, reduction of neurotransmitter receptors and Ca2+ homeostasis, disruption of multiple signal transduction pathways, loss of cell protection, and perhaps most notably, mitochondrial oxidative phosphorylation/energy metabolism are associated with APOE3/4 and APOE4/4 AD alleles. These findings may help define the mechanisms that APOE4 contribute that increase risk for AD and identify new candidate genes conferring susceptibility to AD.

A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. Publishing Authors By Initials

PT Xu,YJ Li,XJ Qin,C Kroner,A Green-Odlum,H Xu,TY Wang,DE Schmechel,CM Hulette,J Ervin,M Hauser,J Haines,MA Pericak-Vance,JR Gilbert,PT Xu,YJ Li,XJ Qin,C Kroner,A Green-Odlum,H Xu,TY Wang,DE Schmechel,CM Hulette,J Ervin,M Hauser,J Haines,MA Pericak-Vance,JR Gilbert,PT Xu,YJ Li,XJ Qin,C Kroner,A Green-Odlum,H Xu,TY Wang,DE Schmechel,CM Hulette,J Ervin,M Hauser,J Haines,MA Pericak-Vance,JR Gilbert,

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A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular and cellular neurosciences

VOLUME: 36

Page Numbers: 313-31

Journal Abbreviation: Mol. Cell. Neurosci.

ISSN: 1044-7431

DAY: 24

MONTH: 07

YEAR: 2007

A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. Information

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LANGUAGE: eng

NlmUniqueID: 9100095

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Grant and Affiliation Information for A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease.

AFFILIATION: Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA. pxu@chg.duhs.duke.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS31 153

ACRONYM: NS

MEDLINETA: Mol Cell Neurosci

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