A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models.

A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models. Abstract Text:

Ina Tesseur,Tony Wyss-Coray,

Neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD) afflict growing numbers of people but treatments are not available or ineffective. These diseases are characterized by the loss of specific neuronal populations, the accumulation of protein aggregates inside and sometimes outside neurons, and an activation of immune pathways in the brain. The causes of sporadic forms of AD or PD are not known but it has been postulated that reduced trophic support to neurons together with age dependent increases in cellular stress lead to chronic injury and ultimately the demise of neurons. TGF-betas are neuroprotective factors and organizers of injury responses and as such might have a role in neurodegenerative disease. We review here the evidence mostly from genetically manipulated mice that links the TGF-beta signaling pathway to neuronal phenotypes and neurodegeneration. Although many of these mutant models did not produce overt CNS phenotypes or adult brain were not studied due to embryonic lethality, there is growing support for a role of TGF-beta signaling in neuronal maintenance, function, and degeneration. Future studies will have to determine whether dysregulation of TGF-beta signaling in neurodegenerative diseases is significant and whether this signaling pathway may even be a target for treatment.

A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models. Publishing Authors By Initials

I Tesseur,T Wyss-Coray,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

PUBMED ID PMID:

MEDLINE DATE:

A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models. Journal Published:

PUBLICATION TYPE: Review

Journal: Current Alzheimer research

VOLUME: 3

Page Numbers: 505-13

Journal Abbreviation:

ISSN: 1567-2050

DAY: 3

MONTH: Dec

YEAR: 2006

A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models. Information

Number of References: 110

LANGUAGE: eng

NlmUniqueID: 101208441

A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: metabolism

Chemical & Substance for Abstract: A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models. Information

Substance Name: Transforming Growth Factor beta

Registry Number: 0

Grant and Affiliation Information for A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models.

AFFILIATION: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

Country: United Arab Emirates

AGENCY: United States NIA

GRANT: AG20603

ACRONYM: AG

MEDLINETA: Curr Alzheimer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models Related Publications

• A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models.
• Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration.
• Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts disease.
• Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins.
• Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis.
• Immune cells may fend off Alzheimer disease.
• Microglia-a wrench in the running wheel?
• Systemic and acquired immune responses in Alzheimer's disease.