A role for proteoglycans in mineralized tissue-titanium adhesion.

A role for proteoglycans in mineralized tissue-titanium adhesion. Research Abstract Details 

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A role for proteoglycans in mineralized tissue-titanium adhesion. Abstract Text:

H K Nakamura,F Butz,L Saruwatari,T Ogawa,

Biomechanical properties of the bone-titanium interface have rarely been studied, due to the technical limitations involved; whether biological bonding mechanisms exist has not been determined. We hypothesized that a selected set of proteoglycan/glycosaminoglycan complexes plays a role in establishing the adhesion between bone and titanium, and utilized the rat bone-marrow-derived osteoblastic culture model to gain an insight into the hypothesis. Gene expression of selected proteoglycan core proteins was up-regulated in the osteoblasts cultured on titanium compared with those on polystyrene. Various sulfated glycosaminoglycans were immunochemically localized at mineralized tissue-titanium interfaces. The administration of various glycosaminoglycan-degrading enzymes into the cultures resulted in a 25-45% reduction of the tissue-titanium interfacial strength, measured by a nanoscratch test; while the hardness and elastic modulus of the mineralized tissue, evaluated by nano-indentation, were not altered. In conclusion, glycosaminoglycan degradation resulted in a decreased interfacial strength between cultured mineralized tissue and titanium, but did not alter the intrinsic strength of the mineralized tissue, suggesting a role for proteoglycan/glycosaminoglycan complexes in the establishment of tissue-titanium adhesion.

A role for proteoglycans in mineralized tissue-titanium adhesion. Publishing Authors By Initials

HK Nakamura,F Butz,L Saruwatari,T Ogawa,

For similar inorganic chemicals: elements: metals, light: titanium research abstracts see: inorganic chemicals: elements: metals, light: titanium research

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A role for proteoglycans in mineralized tissue-titanium adhesion. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of dental research

VOLUME: 86

Page Numbers: 147-52

Journal Abbreviation: J. Dent. Res.

ISSN: 0022-0345

DAY: 3

MONTH: Feb

YEAR: 2007

A role for proteoglycans in mineralized tissue-titanium adhesion. Information

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LANGUAGE: eng

NlmUniqueID: 354343

A role for proteoglycans in mineralized tissue-titanium adhesion. Keywords Mesh Terms:

KEYWORDS: Titanium

MESH TERMS: physiology

Chemical & Substance for Abstract: A role for proteoglycans in mineralized tissue-titanium adhesion. Information

Substance Name: Titanium

Registry Number: 7440-32-6

Grant and Affiliation Information for A role for proteoglycans in mineralized tissue-titanium adhesion.

AFFILIATION: The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, California 90095-1668, USA.

Country: United States

AGENCY: United States NIBIB

GRANT: EB004379

ACRONYM: EB

MEDLINETA: J Dent Res

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