A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex.

A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Abstract Text:

R T Robertson,J Baratta,J Yu,K M Guthrie,

This study examined the relationship between expression of neurotrophin-3 (NT-3) and the ingrowth of cholinergic axonal projections in cerebral cortex. Patterns of expression of NT-3 (defined by beta-galactosidase reporter expression in heterozygous offspring of transgenic NT-3(lacZneo/+) mice) revealed that limbic cortical regions (including frontal, cingulate, and insular cortex, as well as the dentate gyrus) express NT-3 and that these cortical regions receive early and relatively dense cholinergic axons (stained for acetylcholinesterase, AChE). Using the dentate gyrus as a model system, studies revealed that expression of the NT-3 reporter parallels, and precedes by approximately 2 days, the ingrowth of AChE positive cholinergic axons. Studies of forebrain organotypic slice cultures demonstrate that basal forebrain-derived cholinergic axons extend into cortical regions in a pattern that mimics the pattern of expression of the NT-3 reporter. Similarly, chimeric co-cultures, combining wild type septum with a slice of hippocampus from heterozygous NT-3(lacZneo/+) mice, demonstrate that cholinergic axons grow into regions of the dentate gyrus that express the NT-3 reporter. Hemisphere slice cultures made from NT-3 knockout mice reveal cholinergic axonal growth into cortex, but these axons do not form the regional pattern characteristic of slice cultures made from wild type or heterozygous NT-3(lacZneo/+) mice. Further, chimeric co-cultures made using slices of wild type septum combined with slices of hippocampus from NT-3 knockout mice demonstrate robust cholinergic axonal growth into the hippocampus, but the cholinergic axons do not form the characteristic preterminal pattern associated with the dentate gyrus. Slice cultures from limbic cortical tissue from the NT-3 null mice do not display exaggerated levels of cell death. In aggregate, these data support the hypothesis that expression of NT-3 by cortical neurons serves to attract basal forebrain cholinergic projections to their target cells in cerebral cortex.

A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Publishing Authors By Initials

RT Robertson,J Baratta,J Yu,KM Guthrie,

For similar enzymes and coenzymes: enzymes: hydrolases: glycoside hydrolases: galactosidases: beta-galactosidase research abstracts see: enzymes and coenzymes: enzymes: hydrolases: glycoside hydrolases: galactosidases: beta-galactosidase research

PUBMED ID PMID:

MEDLINE DATE:

A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuroscience

VOLUME: 143

Page Numbers: 523-39

Journal Abbreviation: Neuroscience

ISSN: 0306-4522

DAY: 13

MONTH: 10

YEAR: 2006

A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7605074

A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Keywords Mesh Terms:

KEYWORDS: beta-Galactosidase

MESH TERMS: metabolism

Chemical & Substance for Abstract: A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Information

Substance Name: beta-Galactosidase

Registry Number: EC 3.2.1.23

Grant and Affiliation Information for A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex.

AFFILIATION: Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697-1280, USA. rtrobert@uci.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS 30109

ACRONYM: NS

MEDLINETA: Neuroscience

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex Related Publications

• A case study of the South Puget Intertribal Planning Agency's comprehensive cancer control planning and community mobilization process.
• A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex.
• An inconvenient truth: the cumulative influence of childhood poverty on health across the lifespan.
• Clinical problems in syphilis.
• Cognitive recovery in socially deprived young children: the bucharest early intervention project.
• Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects.
• Evolution of small nuclear RNAs in S. cerevisiae, C. albicans, and other hemiascomycetous yeasts.
• Impaired specific autobiographical memory as a risk factor for posttraumatic stress after trauma.
• Isolation of brucella from apparently healthy individuals.
• Maladaptive self-appraisals before trauma exposure predict posttraumatic stress disorder.
• Molecular epidemiology of the African horse sickness virus S10 gene.
• Neurotrophic factors: are they axon guidance molecules?
• New findings from non-linear longitudinal modelling of menopausal hormone changes.
• Nutrition services and foods and beverages available at school: results from the School Health Policies and Programs Study 2006.
• Prevalence and correlates of illicit methylphenidate use among 8th, 10th, and 12th grade students in the United States, 2001.
• Radiotherapy in poor risk patients with stage I cancer of the endometrium: results of not giving external beam radiotherapy.
• Relation of emotion-related regulation to children's social competence: a longitudinal study.
• Relative abundance and prevalence of selected Borrelia infections in Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) from publicly owned lands in Monmouth County, New Jersey.
• Response of olfactory axons to loss of synaptic targets in the adult mouse.
• Studies of a purine-requiring mutant strain of Escherichia coli.
• Talking straight about emergency contraception.
• The UK Advanced Training Course in Liaison Psychiatry: A 13-year review.
• The relationship of the milking machine to mastitis.
• The rise and progress of medical education in Scotland.
• The use of aminized and phosphorylated cotton fabrics as ion exchange materials in the preparation of oil seed proteins.
• Toxic sublingual goiter.
• Utility of morbidity and mortality conference in end-of-life education in the neonatal intensive care unit.
• Vaginitis emphysematosa associated with an abnormal Pap smear.
• [Not Available.]
• [RECENT PROGRESS IN THE CAMPAIGN AGAINST CHRONIC DISEASE.]