A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome.

A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. Research Abstract Details 

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A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. Abstract Text:

Katharine A Kevill,Vineet Bhandari,Mika Kettunen,Lin Leng,Juan Fan,Yuka Mizue,James D Dzuira,Miguel Reyes-Mugica,Courtney L McDonald,John A Baugh,Christine L O'Connor,Zubair H Aghai,Seamas C Donnelly,Alia Bazzy-Asaad,Richard J Bucala,Katharine A Kevill,Vineet Bhandari,Mika Kettunen,Lin Leng,Juan Fan,Yuka Mizue,James D Dzuira,Miguel Reyes-Mugica,Courtney L McDonald,John A Baugh,Christine L O'Connor,Zubair H Aghai,Seamas C Donnelly,Alia Bazzy-Asaad,Richard J Bucala,

Using a mouse model of neonatal respiratory distress syndrome (RDS), we demonstrate a central role for macrophage migration inhibitory factor (MIF) in lung maturation at the developmental stage when human neonates are most susceptible to RDS. We prematurely delivered mouse pups at embryonic day 18, during the early saccular stage of pulmonary development. Only 8% of the prematurely delivered pups genetically deficient in MIF survived 8 h vs 75% of wild-type controls (p < 0.001). This phenotype was corrected when pups of all genotypes were bred from dams heterozygote for MIF deficiency. Local production of MIF in the lung increased at embryonic day 18, continued until full-term at embryonic day 19.5, and decreased in adulthood, thus coinciding with this developmental window. The lungs of pups genetically deficient in MIF were less mature upon histological evaluation, and demonstrated lower levels of vascular endothelial growth factor and corticosterone - two factors that promote fetal lung maturation. In vitro studies support a role for MIF in surfactant production by pulmonary epithelial cells. In a cohort of human neonates with RDS, higher intrapulmonary MIF levels were associated with a lower likelihood of developing bronchopulmonary dysplasia, a sequelae of RDS (p < 0.03). This study demonstrates for the first time a role for MIF in lung maturation, and supports a protective role for MIF in newborn lung disease.

A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. Publishing Authors By Initials

KA Kevill,V Bhandari,M Kettunen,L Leng,J Fan,Y Mizue,JD Dzuira,M Reyes-Mugica,CL McDonald,JA Baugh,CL O'Connor,ZH Aghai,SC Donnelly,A Bazzy-Asaad,RJ Bucala,KA Kevill,V Bhandari,M Kettunen,L Leng,J Fan,Y Mizue,JD Dzuira,M Reyes-Mugica,CL McDonald,JA Baugh,CL O'Connor,ZH Aghai,SC Donnelly,A Bazzy-Asaad,RJ Bucala,

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A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 180

Page Numbers: 601-8

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Jan

YEAR: 2008

A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

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Grant and Affiliation Information for A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome.

AFFILIATION: Department of Pediatrics.

Country: United States

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MEDLINETA: J Immunol

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