A role for IkappaB kinase 2 in bipolar spindle assembly.

A role for IkappaB kinase 2 in bipolar spindle assembly. Research Abstract Details 

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A role for IkappaB kinase 2 in bipolar spindle assembly. Abstract Text:

Jeffrey T Irelan,Thomas J Murphy,Paul D DeJesus,Hsiangling Teo,Dingyue Xu,Maria A Gomez-Ferreria,Yingyao Zhou,Loren J Miraglia,Daniel R Rines,Inder M Verma,David J Sharp,Vinay Tergaonkar,Sumit K Chanda,

IkappaB kinase 2 (IKK2 or IKKbeta) is a component of the IKK complex that coordinates the cellular response to a diverse set of extracellular stimuli, including cytokines, microbial infection, and stress. In response to an external stimulus, the complex is activated, resulting in the phosphorylation and subsequent proteasome-mediated degradation of IkappaB proteins. This event triggers the nuclear import of the NF-kappaB transcription factor, which activates the transcription of genes that regulate a variety of fundamental biological processes, including immune response, cell survival, and development. Here, we define an essential role for IKK2 in normal mitotic progression and the maintenance of spindle bipolarity. Chemical and genetic perturbation of IKK2 promotes the formation of multipolar spindles and chromosome missegregation. Depletion of IKK2 results in the deregulation of Aurora A protein stability and coincident hyperactivation of a putative Aurora A substrate, the mitotic motor KIF11. These data support a function for IKK2 as an antagonist of Aurora A signaling during mitosis. Additionally, our results indicate a direct role for IKK2 in the maintenance of genome stability and underscore the potential for oncogenic consequences in targeting this kinase for therapeutic intervention.

A role for IkappaB kinase 2 in bipolar spindle assembly. Publishing Authors By Initials

JT Irelan,TJ Murphy,PD DeJesus,H Teo,D Xu,MA Gomez-Ferreria,Y Zhou,LJ Miraglia,DR Rines,IM Verma,DJ Sharp,V Tergaonkar,SK Chanda,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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A role for IkappaB kinase 2 in bipolar spindle assembly. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 16940-5

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 15

MONTH: 10

YEAR: 2007

A role for IkappaB kinase 2 in bipolar spindle assembly. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

A role for IkappaB kinase 2 in bipolar spindle assembly. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: drug effects

Chemical & Substance for Abstract: A role for IkappaB kinase 2 in bipolar spindle assembly. Information

Substance Name: Protein-Serine-Threonine Kinases

Registry Number: EC 2.7.11.1

Grant and Affiliation Information for A role for IkappaB kinase 2 in bipolar spindle assembly.

AFFILIATION: Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, CA 92121, USA.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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