A role for dietary selenium and selenoproteins in allergic airway inflammation.

A role for dietary selenium and selenoproteins in allergic airway inflammation. Research Abstract Details 

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A role for dietary selenium and selenoproteins in allergic airway inflammation. Abstract Text:

Peter R Hoffmann,Claude Jourdan-Le Saux,Fukun W Hoffmann,Peter S Chang,Oana Bollt,Qingping He,Elizabeth K Tam,Marla J Berry,

Asthma is driven by allergic airway inflammation and involves increased levels of oxidative stress. This has led to speculation that antioxidants like selenium (Se) may play important roles in preventing or treating asthma. We fed diets containing low (0.08 parts per million), medium (0.25 parts per million), or high (2.7 parts per million) Se to female C57BL/6 mice and used an established OVA challenge protocol to determine the relationship between Se intake and the development of allergic airway inflammation. Results demonstrated that mice fed medium levels of Se had robust responses to OVA challenge in the lung as measured by lung cytokine levels, airway cellular infiltrate, eosinophilia, serum anti-OVA IgE, airway hyperreactivity, goblet cell hyperplasia, and phosphorylated STAT-6 levels in the lung. In contrast, responses to OVA challenge were less robust in mice fed low or high levels of Se. In particular, mice fed low Se chow showed significantly lower responses compared with mice fed medium Se chow for nearly all readouts. We also found that within the medium Se group the expression of lung glutathione peroxidase-1 and liver selenoprotein P were increased in OVA-challenged mice compared with PBS controls. These data suggest that Se intake and allergic airway inflammation are not related in a simple dose-response manner, which may explain the inconsistent results obtained from previous descriptive studies in humans. Also, our results suggest that certain selenoproteins may be induced in response to Ag challenges within the lung.

A role for dietary selenium and selenoproteins in allergic airway inflammation. Publishing Authors By Initials

PR Hoffmann,C Jourdan-Le Saux,FW Hoffmann,PS Chang,O Bollt,Q He,EK Tam,MJ Berry,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, helper-inducer: th2 cells research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, helper-inducer: th2 cells research

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A role for dietary selenium and selenoproteins in allergic airway inflammation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 3258-67

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Sep

YEAR: 2007

A role for dietary selenium and selenoproteins in allergic airway inflammation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

A role for dietary selenium and selenoproteins in allergic airway inflammation. Keywords Mesh Terms:

KEYWORDS: Th2 Cells

MESH TERMS: immunology

Chemical & Substance for Abstract: A role for dietary selenium and selenoproteins in allergic airway inflammation. Information

Substance Name: Glutathione Peroxidase

Registry Number: EC 1.11.1.9

Grant and Affiliation Information for A role for dietary selenium and selenoproteins in allergic airway inflammation.

AFFILIATION: Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawai'i, 651 Halo Street, Honolulu, HI 96813, USA. peterh@pbrc.hawaii.edu

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK 52963

ACRONYM: DK

MEDLINETA: J Immunol

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