A review of clinical studies carried out in Italy with almitrine bismesylate.

A review of clinical studies carried out in Italy with almitrine bismesylate. Research Abstract Details 

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A review of clinical studies carried out in Italy with almitrine bismesylate. Abstract Text:

V Grassi,C Tantucci,C A Sorbini,C Grassi,I Cerveri,C Rampulla,G Bottino,A Giacometti,A Blasi,A Pezza,

The authors refer to a double-blind versus placebo multicentric study, carried out in Italy on 128 hypoxaemic patients suffering from COLD, with Almitrine bismesylate, a new chemoreceptor stimulant drug, given by mouth for a period of two months. Almitrine induced significant changes (p less than 0.001) of PaO2, with a mean increase of 7.6 mmHg, and of PaCO2, with a mean decrease of 4.1 mmHg, without variations of lung volumes and caliber of large and/or small airways. Almitrine, well tolerated within the time limits of this trial, seems an effective oral respiratory drug, acting through a favourable effect on V/Q mismatching due mainly to a reduction of the shunt effect, but also to an improvement of the ventilatory pattern.

A review of clinical studies carried out in Italy with almitrine bismesylate. Publishing Authors By Initials

V Grassi,C Tantucci,CA Sorbini,C Grassi,I Cerveri,C Rampulla,G Bottino,A Giacometti,A Blasi,A Pezza,

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: piperazines research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: piperazines research

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A review of clinical studies carried out in Italy with almitrine bismesylate. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of respiratory diseases. Suppleme

VOLUME: 146

Page Numbers: 671-6

Journal Abbreviation:

ISSN: 0106-4347

DAY: 21

MONTH: 02

YEAR: 1986

A review of clinical studies carried out in Italy with almitrine bismesylate. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8010618

A review of clinical studies carried out in Italy with almitrine bismesylate. Keywords Mesh Terms:

KEYWORDS: Piperazines

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: A review of clinical studies carried out in Italy with almitrine bismesylate. Information

Substance Name: Almitrine

Registry Number: 27469-53-0

Grant and Affiliation Information for A review of clinical studies carried out in Italy with almitrine bismesylate.

AFFILIATION:

Country: DENMARK

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MEDLINETA: Eur J Respir Dis Suppl

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