A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy.

A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy. Abstract Text:

Michele P Lambert,Carol Shields,Anna T Meadows,Michele P Lambert,Carol Shields,Anna T Meadows,Michele P Lambert,Carol Shields,Anna T Meadows,

BACKGROUND: Retinoblastoma occurs in approximately 4 per million children per year in the United States, usually before 2 years of age. In developed countries, 95% of children with tumor in one eye can be cured with enucleation, while children with tumor in both eyes require individualized therapy to preserve vision. Although enucleation and radiation are very effective therapies for children with bilateral disease, the resultant visual impairment, cosmetic deformity and risk for new tumors result in morbidity to these children who otherwise have a near normal lifespan. Therefore, since 1994, chemoreduction with vincristine, carboplatin, and etoposide combined with focal treatment, have been used successfully. However, a major concern with the use of carboplatin has been ototoxicity. PROCEDURES: To determine whether carboplatin, in the doses and schedule used by us and others to treat retinoblastoma (18.6 mg/kg q 4 weeks for six cycles) results in hearing impairment, we reviewed the records of 248 children with retinoblastoma, 164 of whom had received carboplatin. Children generally received carboplatin, vincristine, and etoposide (CEV) for six cycles of chemotherapy. RESULTS: Hearing evaluations prior to initiating therapy were abnormal in 14 patients (5.6%). No patients with normal initial audiograms were found to have abnormal studies following repeated evaluations. CONCLUSION: While ototoxicity is a potential concern in this young patient population, carboplatin in the treatment of retinoblastoma does not appear to produce impairment. Screening can identify children who require frequent audiologic follow-up, but children whose hearing is normal prior to therapy do not require routine surveillance following six cycles of standard CEV therapy. Pediatr Blood Cancer 2008;50:223-226. (c) 2007 Wiley-Liss, Inc.

A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy. Publishing Authors By Initials

MP Lambert,C Shields,AT Meadows,MP Lambert,C Shields,AT Meadows,MP Lambert,C Shields,AT Meadows,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pediatric blood & cancer

VOLUME: 50

Page Numbers: 223-6

Journal Abbreviation:

ISSN: 1545-5017

DAY: 12

MONTH: Feb

YEAR: 2008

A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101186624

A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy.

AFFILIATION: Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA & Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pediatr Blood Cancer

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy Related Publications

• A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy.
• Bronchospasm during excretory urography: lack of specificity for the methylglucamine cation.
• CT of sarcomatous degeneration in neurofibromatosis.
• Case 1: Psychological feeding disorder? (Case Presentation).
• Case 1: Psychological feeding disorder? (Discussion and Diagnosis).
• Case report: a patient with anti-'N'.
• Chronic alcohol consumption perturbs the balance between thymus-derived and bone marrow-derived natural killer cells in the spleen.
• Classifying the intensity of pediatric cancer treatment protocols: the intensity of treatment rating scale 2.0 (ITR-2).
• EXPERIMENTAL CLINIC FOR PREVENTING CHRONIC BRONCHITIS.
• Elder mistreatment in the nursing home: a systematic review.
• Evidence-based assessment, intervention and psychosocial care in pediatric oncology: a blueprint for comprehensive services across treatment.
• Factors involved in modulation of NK cell activity by ethanol consumption.
• HEALTH EXAMINATIONS OF SENIOR STAFF IN INDUSTRY.
• Implant technology and usability.
• Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells.
• Neurology; medical.
• Precorneal residence time of artificial tears measured in dry eye subjects.
• Retinoblastoma: approaching international standards for recommending chemotherapy (Commentary on Chantada et al., page 692).
• Rhabdomyosarcoma presenting as a calf pyomyositis.
• SCINTILLATION SCANNING OF BRAIN TUMORS.
• Selective amino acid restriction differentially affects the motility and directionality of DU145 and PC3 prostate cancer cells.
• Skeletal metastases from cerebellar medulloblastoma.
• Specific amino acid dependency regulates the cellular behavior of melanoma.
• Sperm banking for adolescent and young adult cancer patients: sperm quality, patient, and parent perspectives.
• Staphylococcal enterotoxins G and I, a cause of severe but reversible neonatal enteropathy.
• Studies on the mechanism of alimentary lysozyme production. II.
• Subtotal gastrectomy or vagotomy for peptic ulcerations; early results and postoperative symptoms.
• Tamanu (Calophyllum inophyllum) - the African, Asian, Polynesian and Pacific Panacea.
• The ferguson medial approach for open reduction of developmental dysplasia of the hip. A clinical and radiological review of 49 hips.
• Transferrin reverses the anti-invasive activity of human prostate cancer cells that overexpress sema3E.